I use switched USB hubs, and an HDMI switch, as kind of a reverse KVM, with my setup.

A traditional KVM will hook one set of controls/monitor to multiple computers.
I need the opposite.

I have one computer which serves two separate rooms, with the cables punched through the wall.
Connected to that computer I have three monitors (one in one room, two in the other), two keyboards, three mice, multiple controllers, cables for Rocksmith, driving controls, headsets, etc...

I am able to turn all of those things on/off with switches in each room, so I'm not having things connected that I don't need at that moment.