UseYourThumb t1_j5uk896 wrote
Could you link the paper? It is hard to know what you are referring to based on this question alone. I'm guessing you are talking about fast or slow afterhyperpolarizations, which are usually mediated by different types of calcium dependent potassium channels with faster or slower kinetics. I suppose you could also be talking about the activation of GABA-A versus GABA-B receptors. GABA-A receptors are ion channels that mediate fast chloride entry into the cell when GABA binds versus GABA-B receptors that are g-protein coupled receptors and act much more slowly.
Unknown_Predator88 OP t1_j5w6sd2 wrote
https://pubmed.ncbi.nlm.nih.gov/16402094/
I also wanted to clarify; My P.I. referred to benzodiazepines as an agonist of GABA, but this paper mentions that they potentiate GABA by increasing channel frequency; this is confusing to me and i have to present an overview of it at our lab meeting on friday. Thanks.
UseYourThumb t1_j5wa8ui wrote
I agree with the paper, I don't think I would technically call it an agonist. Read sections 6, 7, and 8 of this more recent review for a better explanation.
Unknown_Predator88 OP t1_j5w6wpw wrote
Yes, I was referring to GABA-A and GABA-B. I apologize
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