Unknown_Predator88 OP t1_j5w6sd2 wrote on January 26, 2023 at 12:00 AM

Reply to comment by UseYourThumb in i was reading an article that mentions GABA and how different isoforms mediate “fast” and “slow” hyperpolarization. what is meant by “fast” and “slow” in the context of hyperpolarization? by Unknown_Predator88

https://pubmed.ncbi.nlm.nih.gov/16402094/

I also wanted to clarify; My P.I. referred to benzodiazepines as an agonist of GABA, but this paper mentions that they potentiate GABA by increasing channel frequency; this is confusing to me and i have to present an overview of it at our lab meeting on friday. Thanks.

UseYourThumb t1_j5wa8ui wrote on January 26, 2023 at 12:25 AM

I agree with the paper, I don't think I would technically call it an agonist. Read sections 6, 7, and 8 of this more recent review for a better explanation.