Recent comments in /f/askscience
Sufficient_Map_8034 t1_j1ua4d4 wrote
Reply to comment by [deleted] in Does the placebo effect "stack"? by amedicalprofessional
"as the patient may become aware that the treatment is not producing a genuine therapeutic effect"
Remarkably the placebo effect even works when patients are told they are receiving a sham treatment.
RavenousOwlhead t1_j1ua43o wrote
Reply to AskScience AMA Series: I'm Here to Talk About Roots and Shoots: How Plants Prosper in the Desert and What it Means for Agriculture and Biodiversity, AMA! by AskScienceModerator
Are there any unique plants other than cacti found in the deserts? It may sound stupid but I am no plant expert but I am curious.
Sea_sharp t1_j1u802n wrote
Reply to AskScience AMA Series: I'm Here to Talk About Roots and Shoots: How Plants Prosper in the Desert and What it Means for Agriculture and Biodiversity, AMA! by AskScienceModerator
Do the desert plants you've studied have mycorrhiza in their roots?
[deleted] t1_j1u77u4 wrote
[deleted] t1_j1u5xyv wrote
Reply to Does the placebo effect "stack"? by amedicalprofessional
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hari2897 t1_j1u4v8g wrote
Reply to AskScience AMA Series: I'm Here to Talk About Roots and Shoots: How Plants Prosper in the Desert and What it Means for Agriculture and Biodiversity, AMA! by AskScienceModerator
If an area that was once extremely fertile becomes deserted and loses all its flora and fauna , will the plants that ever grow there later be something similar to cactus ? How did plants like Cactus 🌵 get into deserts ? Is it due to millions of years of evolution in that specific area ? I'm supposing , for something like cactus to evolve , that area should have been a desert for millions and millions of years such that there was enough time for something like cactus to evolve. So what happens due to our deforestation? How long before things spring back ?
[deleted] t1_j1u1r8z wrote
[deleted] t1_j1tz1qu wrote
Reply to Does the placebo effect "stack"? by amedicalprofessional
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Lepmuru t1_j1tywt5 wrote
The immune system is very adapt in recognizing foreign biological matter like bacteria, viruses and even another eucaryote organism's cells.
On the other hand, the body selects it's own immune cells for low responsiveness to its own proteins to prevent autoimmunity.
Cancer is essentially constituted of a body's very own cells gone aberrant. That means, these cells usually share several of the following characteristics:
- Internally and/or externally unregulated growth, proliferation, and expansion
- Loss of tissue function
- Migration to neighbouring tissues
- Denial of internal and/or external apoptotic stimuli (self-destruction)
- Evasion of immune cell recognition
- Inhibition of immune cell signalling
To break it down in terms of your question: cancer cells are naturally less likely to be targeted by immune cells than external pathogens, as they are basically a body's own cells. Immune cells, nevertheless, will kill wildly aberrant cells rapidly. That basically means cancer cells are naturally selected for variants that circumvent this line of defense. Either, they lose receptors by which they are primarily recognized by immune-cells, or gain/upregulate mechanisms by which they suppress immune cell-responses despite proper recognition.
Now, mRNA vaccines can reverse these effects by different mechanisms. You could potentially use them to
- increase the expression of receptors the immune cells use naturally
- decrease the expression of receptors inhibiting immune cell response
- introduce new epitopes the body knows how to react to, like surface proteins of a bacterium
All of these increase efficiency, efficacy and precision of the immune cell response against the targeted tumor cell.
[deleted] t1_j1ttm5k wrote
[deleted] t1_j1tratg wrote
Reply to comment by mjbat7 in In Sci-Fi the concept of eye-transplants is common enough - what would it take to actually be able to do it? by Daniel_Jacksson
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nubsauce87 t1_j1tramt wrote
Reply to comment by athomasflynn in In Sci-Fi the concept of eye-transplants is common enough - what would it take to actually be able to do it? by Daniel_Jacksson
Bionic eyes already exist. There was a story this year about how a handful of people who had them went blind because the company that designed them went out of business and stopped supporting them.
Spectacularsunsets t1_j1tpets wrote
Reply to comment by Racklefrack in Why are there deserts near the coast? How come they don't get more rain, despite being near to a large body of water with plenty of sun and evaporation? by milton117
Another example is the dry lands west of the great dividing range in Australia
ActiveLlama t1_j1tmysw wrote
Reply to Why are there deserts near the coast? How come they don't get more rain, despite being near to a large body of water with plenty of sun and evaporation? by milton117
Rain usually happens because the hot air around the ocean carries water up above into the air and then falls into the land. Due to the rotation of the earth the prevailing wind mostly goes from east to west near the equator. Sometimes due to the mountains or due to the large stretches of land between the west coast and the east seas, rain is unable to reach the western coast. When the humid air from the east doesn't reach the west coast a coastal dessert forms. Even if there is some sea on the west, it evaporates and carries the rain to the west, not to the east.
This is a simplified explanation, since there are other factors to consider such as the temperature of the oceans, latitude, lakes, rivers, seasonality of the air currents or the direction of the prevailing winds.
[deleted] t1_j1tjie0 wrote
Reply to comment by Tappitss in How do they know what the inside of the earth is made of, along with the internal temperatures? by Kozzinator
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mjbat7 t1_j1thvo8 wrote
Reply to comment by athomasflynn in In Sci-Fi the concept of eye-transplants is common enough - what would it take to actually be able to do it? by Daniel_Jacksson
Bionic eyes are currently in development by the bionic ear team and they aren't that far away, although it'll probs start with simple shapes with poor resolution. But it's a simpler problem because you can interrogate the patient's optic nerve and augment stimuli to inform the way your device communicates.
On the other hand, transplants are much more challenging - the visual pathway from cone/rod passes through complex, multi-synapse neuronal processing. Neurons tend to degrade quickly and they aren't very good at repair. Then there's the rejection question. So you don't have a good way to figure out if you're connecting the right donor/patient neurons, and even if you did, they'd rapidly degrade.
Brain_Hawk t1_j1thr3n wrote
Reply to In Sci-Fi the concept of eye-transplants is common enough - what would it take to actually be able to do it? by Daniel_Jacksson
A full eye transplant would require detaching the retinal nerve and grafting it on to someone else, which is not currently a feasible form of technology. If we could perform those kind of nerve graphs, we could repair damaged spines and restore people who are paralyzed from spine severing. To the best of my knowledge this is still generally impossible.
The optic nerve carries information from different parts of the retina to the brain in a very specific way. This means essentially we would have to be able to one-to-one remap and reconnect nerves at the level of single axons, extremely microscopic it involving tens of thousands or hundreds of thousands of specific connections. It's not as simple as taking one nerve and then smashing it to another and hope they all link up. If we could get random events to link up together, the person receiving the eye transport plan would essentially receive White Noise Vision to their brain, with everything all mixed up and wrong.
We can currently do cornea transplants, and fun side bar, some recent advancement in transplanting retinal cells and restoring Vision when people have damage to the retina
Personally I believe the widespread use of bionic style and implants, such as a robotic eye, will never become a big thing because the biology will outpace the engineering. So at least from a recovery of function perspective I don't think it'll take off. It's always possible that doesn't the form of human enhancement, for example producing biotic eyes that have different kinds of vision. But I think the biology will be a lot faster
[deleted] t1_j1thd0g wrote
ARoundForEveryone t1_j1thbr3 wrote
Reply to comment by [deleted] in Does the placebo effect "stack"? by amedicalprofessional
Is this known as the "Fool me once, shame on you but fool me twice, shame on me" effect?
leo_agiad t1_j1tenia wrote
Reply to Why are there deserts near the coast? How come they don't get more rain, despite being near to a large body of water with plenty of sun and evaporation? by milton117
So, let's take an obvious one like Namibia. Namibia has a very cold current running north up it's coast called the Benguela. It is quite cold. The air above it is also quite cold, and therefore dry.
This cold air hits the hot desert dunes and warms rapidly and heads straight up. Very little moisture makes it inland.
So temperature difference between land and sea due to ocean and wind currents can cause the situation you are describing.
Hockeygoalie35 t1_j1tekzy wrote
Reply to comment by whyyou- in What happens if a mother‘a child has a non-compatible blood type? What will happen when she is pregnant? by thebookklepto
I was an RH Disease baby. Needed several blood transfusions while still in the uterus, was born 10 weeks premature for further transfusions.
[deleted] t1_j1tbrkz wrote
Reply to Does the placebo effect "stack"? by amedicalprofessional
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[deleted] t1_j1tayd4 wrote
adamgerges OP t1_j1ta63g wrote
Reply to comment by DudoVene in How does mRNA vaccine help the immune system identify cancer cells? by adamgerges
as the other commenter said, this doesn’t answer the question of why need the mRNA vaccine to activate that response from the immune system when those chemicals are already present in cancerous cells in the body
hey-look-over-there t1_j1uaejj wrote
Reply to AskScience AMA Series: I'm Here to Talk About Roots and Shoots: How Plants Prosper in the Desert and What it Means for Agriculture and Biodiversity, AMA! by AskScienceModerator
What's some tasty plants I can grow in Nevada or Arizona desert/drought? Also would it be possible to grow agave (for tequila and syrup) industrially in desert regions?