Recent comments in /f/askscience

Prestigious_Carpet29 t1_j36fn03 wrote

I have a broad knowledge of physics and engineering, but pressing/stamping is not my particular area of expertise.

The Wikipedia image linked by HankScorpi-vs-the-World indicates feature sizes almost as small as 100nm for Blu-ray (that's maybe a factor of 2- or 3 smaller than I was expecting, but may well be correct).

I suspect the problem of how small features can be pressed comes down to economics: I expect the metal stamping tool will wear with use, so that as the feature sizes get smaller probably you get get fewer good-quality stampings out of it before you need a new tool.

Although progress is being made in making LEDs deeper into the ultraviolet, given that once you get into the UVB range the light is strongly absorbed by plastic lenses and discs, I can't imagine this technology has a whole lot further to run anyway.

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Disastrous-Topic-712 t1_j36e5sf wrote

A TENS-stimulator works by inhibiting the pain stimulating pathways in your spine that are usually too active in chronic pain. Chronic pain results in lowering your pain tolerance. By sending electrical signals via stickers on your back, this happens less. Doesn't help everyone, but it definitely works for quite some people.

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Corvis_74 t1_j36bkg0 wrote

The soaking is probably to get out water soluble iron or calcium compounds that, while not unwholesome, might impart an unwelcome rust or chalky flavor to the first dishes cooked in it. The olive oil is to put a food safe coating into the pores and surfaces. I’d imagine being particular about the oil is sticking with the known procedure to avoid experiments with adverse results

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A-C01 t1_j369na1 wrote

I think SimShade made a beautiful recap but there is something that may be useful to add. I am an MD but not an immunologist so someone could sure be more accurate. It is true that there may be some variability in our self molecules/proteins/antigens (due to SNPs and other reasons). However the main parts (those with an active function such as enzymatic activity, receptor function etc) are usually conserved among individuals and sometimes among species. A lot of variability is found in the MHC molecules that have a key role in antigen recognition and presentation. This can explain in part why autoimmune disease develop more frequently in some individuals and the association with the HLA aplotype. Moreover, often when autoantibodies develop against some self-antigens (ex. anti-insulin antobodies or anti-TPO antibodies etc) there are different antibodies against different epitopes of the same molecule (polyclonal response). This is probably one of the main reasons why the tests for autoimmunity are quite accurate (because we usually don’t test for epitope specific antibodies even if it can be done using some specific tests). I hope this helps but a very useful test is: “Cellular and Molecular Immunology” by Abbas et al.

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SignalDifficult5061 t1_j3619jj wrote

Yeah, I thought so too. Then again, there are some enzymes that somehow outperform the theoretical maximum diffusion constant. Something about formate as a substrate.

I'm terrified if I talk about this some jerkwad will make some association with a vaccine or aquarium cleaner, and I don't like responsibility.

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aspheric_cow t1_j35n22k wrote

A faster ascent does take less energy - not because the gravity is stronger at lower altitude (the difference is pretty minor) but because the rocket spends more time fighting gravity. Think about the extreme case where the rocket is barely moving up - it will use up all fuel before it gets to any meaningful altitude. It's kind of like walking up a downward escalator - you have to expend energy just to stay in one place, and it's actually easier to run up quickly. Once you're at the top (in orbit), you can stay there without using any energy.

But there are limits on how quickly a rocket can accelerate, such as:

  • Quick acceleration requires more powerful engines. The engines themselves get heavier. This is mainly an issue with liquid-fuel rockets; solid fuel rockets don't really have an "engine" and you could design it to burn all the fuel very quickly if you want to.
  • The quicker you accelerate, the more G force & vibration the payload experiences. This is especially a problem if the "payload" is people.
  • If you accelerate hard, you end up traveling very fast through the dense low-altitude atmosphere, which means a lot of mechanical stress & vibration on the rocket.
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