Recent comments in /f/askscience

RobusEtCeleritas t1_j4pffai wrote

When uranium-235 interacts with a neutron, sometimes you get fission, and sometimes you get other processes, like radiative capture. When uranium-235 captures the neutron and de-excites via gamma emission, what's left over is uranium-236.

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joalheagney t1_j4pbw10 wrote

Because you can just allow more heat to go up a tall, well designed/balanced chimney, at a lower fuel to heat efficiency, than taking that heat, converting it to electricity, then to kinetic energy.

Same overall effect with extra (unnecessary) steps. Chemical PE -> heat (-> electricity) -> kinetic energy -> gravitational PE.

A better overall strategy is mass heater fires, like mass heater rocket stoves, or Scandinavian masonry stoves. Burn a small fire, hot, fast and about 70% efficient. Let the heat soak into a massive thermal mass and allow the heat to slowly soak out into the dwelling.

An even better solution are Chinese fire-beds, where you sleep directly on a very flat, very short stove. Heat the body, not the house.

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joalheagney t1_j4pb3u8 wrote

The other big issue is the driving gas. You want something with a really low molecular mass for maximum thermal expansion. Hydrogen gas would be ideal if it didn't have a distressing tendency to diffuse into and through metals. And. You know. Explode in contact with heat and Oxygen.

Helium is half as good (twice the MM) ... but incredibly expensive and almost as hard to contain. Doesn't explode though which is good.

And then you're into N2, O2 and you may as well use air for obvious reasons. At about 14 times the MW of hydrogen gas. :/

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marypoppindatpussy t1_j4p4v5t wrote

yes this also happens naturally in the brain. this is the basis of synaptic plasticity, the mechanism by which we learn. i'm gonna make the distinction though that the electrical potential at which the neuron fires does not change, rather it is the number of receptors on the surface of the cell that changes. these receptors modulate the amount of ions that can flow into/out of the cell and that causes a change in the membrane potential of the cell which leads to it firing.

so changing the electrical potential at which the cell fires is not something we can safely change as it alters way too much about how the cell works in general (and depending on how you do it can kill the organism), but manipulating (with drugs, genetic manipulation) the receptors on the cell surface that modulate the ion flow in/out of the cell is safer and more built for tweaking.

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marypoppindatpussy t1_j4p3bd9 wrote

i'm confused, was your question about changing the dna sequence of just one protein, leaving all the rest of the dna unchanged? that's how i interpreted it. but askoemnzviwcasf seems to have interpreted the question as you changed all parts of dna that code for a protein. was their interpretation correct?

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marypoppindatpussy t1_j4p2y5o wrote

i agree with the other comments on genes vs alleles and that it is often more complicated than recessive/dominant as in u/atomfullerene's example with blood types. but if i'm understanding what you meant, i think the question you were getting at is can a rare/generally considered detrimental allele become beneficial and widespread in a population.

if that's what you were asking, the answer is yes. and in terms of time, it would depend on how beneficial the allele is. an example is sickle cell anemia. Whilst it's normally a rare and detrimental mutation, it became pretty widespread in africa because it can be protective against malaria. In this situation the death from malaria was more frequent than the death from sickle cell, at least before the child-bearing ages, so this change was decently fast. here's a link if you're interested in reading more about this: https://sickle-cell.com/clinical/malaria

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