Recent comments in /f/askscience

Sylvurphlame t1_j503s5f wrote

Difficult but not impossible. So with uncountable attempts at reproduction every generation you eventually get viable offspring with differing numbers of chromosomes that can branch off into their own species.

It’s a large numbers game.

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CharlesOSmith t1_j503c3s wrote

It's also important to know, that in the case of resveratrol, you can't just look up the literature and get an understanding of how effective it is. There was a fairly large scandal in the field around 2012 which was closely followed by the watchdog site retractionwatch. Now while one researcher publishing fraudulent data does not mean the entire field of research is wrong, it does mean each and every paper needs to be carefully scrutinized to see how heavily it relied on background assumptions made by papers that were later shown to be false. In this case in particular, with the researcher publishing over a hundred of papers a year some highly sited that left a pretty big impact. I can't say for sure how strongly this was felt in the longevity research community, but in the field of cardioprotection, which I was in at the time, it was a big deal.

Even a fairly recent review, which is by in large well and fairly balanced regarding the literature still cites papers from this researcher' publications and doesn't mention that aspect of the field's history at all.

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almostbig t1_j4zzqxb wrote

/u/fruticosa explained here how genes end up being duplicated and suffer mutations throughout a timeline.Ricin comes from a unfortunate chain of events driven solely by evolutionary pressure and the randomness of nature.

The A chain of the protein, the one which inhibits the ribossomes, which causes it to effectively be toxic. It, among other similar ribossome-inhibiting proteins, has originated from a presumably defense-related protein that existed in an early angiosperm species.

It underwent it's own mutations over the ages, ended up being, in some of the higher plants, a gene that is duplicated several times and expressed differently in multiple phases of plant development, remember, not necessarily that means it has any function.

In some, however, it ended up becoming associated with another chain, the B chain. The B chain itself has originated from simple sugar-binding proteins, which basically any living being has in it's cytoplasm. Through the odds and evolutionary pressure, it ended up turning into a galactoside-binding chain.

That B chain, associated with A chain, is what is up with ricin. The galactoside-binding chain, once in our bodies, will bind with cell surface sugars, which therefore leads the cell to take the whole protein inside via endocytosis. Ribossomes are key parts of protein synthesis, their disruption by the A chain will lead to death in eukaryotic cells.

basically, two early proteins that were not really related at all went through numerous mutations, "fused" and originated it. At later evolutionary points, the dimer gene itself went through duplications and more modifications, coding for toxin-like proteins we see in some plants, but that's not the point.

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bigflamingtaco t1_j4zxrx2 wrote

I don't think we're on the same page here. I'm talking about using a tec fan with a portable propane heater instead of using batteries to run its internal fan, not using tec fans as a solution for all heat distribution requirements. You use tec fans with Mr Heater style propane burners and micro stoves as often used for winter camping. If you're running your buck stove in the living room and want to distribute the heat to the other end of the house, tec fans aren't going to do it.

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