Recent comments in /f/askscience
[deleted] t1_j506cae wrote
Reply to comment by L0cked4fun in Is there any difference in efficacy when a vaccine is administered somewhere other than the upper arm (e.g. on the foot)? by MercurioLeCher
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[deleted] t1_j506bb0 wrote
LibertarianAtheist_ t1_j506b55 wrote
Reply to comment by lemoinem in Is time divided up into discrete quanta? Is time "quantized"? by NulloK
What did they write?
firstfrontiers t1_j5061lt wrote
Reply to comment by boooooooooo_cowboys in Is there any difference in efficacy when a vaccine is administered somewhere other than the upper arm (e.g. on the foot)? by MercurioLeCher
To my understanding you're trying to get it absorbed into the bloodstream, which is why you aim for muscle which is highly vascular tissue
[deleted] t1_j505wqx wrote
Reply to comment by dryingsocks in Is there any difference in efficacy when a vaccine is administered somewhere other than the upper arm (e.g. on the foot)? by MercurioLeCher
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boooooooooo_cowboys t1_j505s4p wrote
Reply to comment by seanmorris in Is there any difference in efficacy when a vaccine is administered somewhere other than the upper arm (e.g. on the foot)? by MercurioLeCher
You’re not trying to get your vaccine into the muscle cells themselves. All the action happens in the draining lymph nodes.
firstfrontiers t1_j505f7w wrote
Reply to comment by seanmorris in Is there any difference in efficacy when a vaccine is administered somewhere other than the upper arm (e.g. on the foot)? by MercurioLeCher
Interesting, I didn't know about this! Do you have any more detail on that?
[deleted] t1_j504wqj wrote
ceelo71 t1_j504e5m wrote
Reply to comment by dryingsocks in Is there any difference in efficacy when a vaccine is administered somewhere other than the upper arm (e.g. on the foot)? by MercurioLeCher
Honestly doctors don’t give shots. Nurses are much better trained and I would trust them over a doctor
[deleted] t1_j503zeq wrote
Sylvurphlame t1_j503s5f wrote
Reply to Given that reproduction is difficult or impossible when both animals have different numbers of chromosomes, how did so many species evolve to have so many different numbers of them? by MercurioLeCher
Difficult but not impossible. So with uncountable attempts at reproduction every generation you eventually get viable offspring with differing numbers of chromosomes that can branch off into their own species.
It’s a large numbers game.
CharlesOSmith t1_j503c3s wrote
Reply to comment by magicfeistybitcoin in What's the current scientific consensus on resveratrol extending lifespan? by pixeleos
It's also important to know, that in the case of resveratrol, you can't just look up the literature and get an understanding of how effective it is. There was a fairly large scandal in the field around 2012 which was closely followed by the watchdog site retractionwatch. Now while one researcher publishing fraudulent data does not mean the entire field of research is wrong, it does mean each and every paper needs to be carefully scrutinized to see how heavily it relied on background assumptions made by papers that were later shown to be false. In this case in particular, with the researcher publishing over a hundred of papers a year some highly sited that left a pretty big impact. I can't say for sure how strongly this was felt in the longevity research community, but in the field of cardioprotection, which I was in at the time, it was a big deal.
Even a fairly recent review, which is by in large well and fairly balanced regarding the literature still cites papers from this researcher' publications and doesn't mention that aspect of the field's history at all.
Lexical3 t1_j502ape wrote
Reply to What specifically keeps viruses from moving from human to animal or vice versa in most cases? by cheekychessie
more simply: nothing but time and chance. Viruses regularly mutate to become infectious to a different proximal host in a process called Zoonosis. It's a large part of why the current avian flu pandemic is so scary- historically, our worst flus are mutated avian variants!
GalFisk OP t1_j5020xl wrote
Reply to comment by almostbig in What does the ricin molecule do in the castor bean? by GalFisk
Very interesting, thanks.
almostbig t1_j500s6z wrote
Reply to comment by DaylightsStories in What does the ricin molecule do in the castor bean? by GalFisk
it has, but not really surprisingly the answer is:
1 - plant make protein for defense
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2 - plant happy
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3 - Florida or whatever happens randomly
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4 - Ricin
almostbig t1_j4zzqxb wrote
/u/fruticosa explained here how genes end up being duplicated and suffer mutations throughout a timeline.Ricin comes from a unfortunate chain of events driven solely by evolutionary pressure and the randomness of nature.
The A chain of the protein, the one which inhibits the ribossomes, which causes it to effectively be toxic. It, among other similar ribossome-inhibiting proteins, has originated from a presumably defense-related protein that existed in an early angiosperm species.
It underwent it's own mutations over the ages, ended up being, in some of the higher plants, a gene that is duplicated several times and expressed differently in multiple phases of plant development, remember, not necessarily that means it has any function.
In some, however, it ended up becoming associated with another chain, the B chain. The B chain itself has originated from simple sugar-binding proteins, which basically any living being has in it's cytoplasm. Through the odds and evolutionary pressure, it ended up turning into a galactoside-binding chain.
That B chain, associated with A chain, is what is up with ricin. The galactoside-binding chain, once in our bodies, will bind with cell surface sugars, which therefore leads the cell to take the whole protein inside via endocytosis. Ribossomes are key parts of protein synthesis, their disruption by the A chain will lead to death in eukaryotic cells.
basically, two early proteins that were not really related at all went through numerous mutations, "fused" and originated it. At later evolutionary points, the dimer gene itself went through duplications and more modifications, coding for toxin-like proteins we see in some plants, but that's not the point.
[deleted] t1_j4zyzg1 wrote
Abu_mohd t1_j4zyk9a wrote
Reply to comment by _HelloMeow in Whats stopping us from sending a probe into a black hole if we haven't already? by stealth941
>unfortunately we can build a spacecraft
I believe this is a typo, s/can/cannot .
Wyg6q17Dd5sNq59h t1_j4zyd33 wrote
Reply to comment by jrob323 in Whats stopping us from sending a probe into a black hole if we haven't already? by stealth941
An Orion-class vehicle can carry with it lots of mass to protect it from relativistic dust collisions.
[deleted] t1_j4zyb8m wrote
Reply to comment by L0cked4fun in Is there any difference in efficacy when a vaccine is administered somewhere other than the upper arm (e.g. on the foot)? by MercurioLeCher
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[deleted] t1_j4zy95z wrote
bigflamingtaco t1_j4zxrx2 wrote
Reply to comment by joalheagney in How do non electric heat operated fans work? by ranman12953
I don't think we're on the same page here. I'm talking about using a tec fan with a portable propane heater instead of using batteries to run its internal fan, not using tec fans as a solution for all heat distribution requirements. You use tec fans with Mr Heater style propane burners and micro stoves as often used for winter camping. If you're running your buck stove in the living room and want to distribute the heat to the other end of the house, tec fans aren't going to do it.
Bax_Cadarn t1_j506f30 wrote
Reply to comment by suvlub in Given that reproduction is difficult or impossible when both animals have different numbers of chromosomes, how did so many species evolve to have so many different numbers of them? by MercurioLeCher
I would like to point out many women can have 45 chromosomes and people with 47 or 48 aren't unheard of either - Turner's and Klinefelter's.