Recent comments in /f/askscience

smnms t1_j50vf70 wrote

Quantum mechanics explains the orbitals of an atom's electrons, and also the molecular orbitals of covalent bonds between atoms. Orbitals are also important for the van-der-Waals forces, hydrogen bonds, and interactions with the molecular orbitals of surrounding water molecules, which direct protein shape.

In the end, all chemistry is applied quantum mechanics, and protein folding is chemistry.

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HornedDiggitoe t1_j50sxod wrote

> Our knowledge of medicine significantly alters our fitness odds, and allows many genes to reproduce that may not have otherwise survived.

Knowledge of medicine can’t be credited for that. That was largely due to human knowledge of farming/agriculture, as well as human empathy to care for the weak. Humans not surviving long enough to reproduce was historically caused more by a lack of food than anything else. If you had a dead weight (disabled) human in your group and not enough food to go around, guess who isn’t going to get fed?

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dkysh t1_j50ssc6 wrote

If we were bacteria, yeah, sure. But we are extremely complicated multicellular organisms. A whole genome trisomy screws up the balance of gene expression to such an extreme that most trisomies are simply lethal and never observed (they end up in miscarriage).

A gene fusion is a less drastic event, where 2 chromosomes happen to be connected, but the genetic load is identical.

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firstfrontiers t1_j50ntmt wrote

There's overlap between medications and some medications can be given either way. However IM is going to be a slower release over time versus being immediately introduced all at once into the bloodstream. I know the form of medication or the substance it comes in plays a role too, some play better with different tissue types (some meds we give into the fat tissue as well depending on absorption). There's also the issue of bleeding risk which would be higher trying to give something IV when it's safer in a clinic setting to just give it IM. But as far as I'm aware the biggest factor is the more controlled release time

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Dro-Darsha t1_j50nokv wrote

It’s not enough to have one or few viable offspring though. Also they have no good way to find each other, so they need to be able to reproduce with the other chromosome count until they reach a critical number

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stickymaplesyrup t1_j50nlvg wrote

Okay, hear me out.

One of the ways we define whether or not species are different is if they can reproduce together, and if the offspring are also able to reproduce. This is why horses and donkeys are still different species even though they can have babies, ie mules, because mules are sterile.

What if these 44 chromosome people grew in number and could have kids together (non-incestuously, I don't know if there are multiple families with this condition)? And then those kids could have kids, and so on.

Would this be the origin of a new species of human?

It's fun to think about and consider.

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Moldy_Teapot t1_j50ndyl wrote

I can't speak to how it would affect the vaccine and the body's response to it, but I can say that giving a vaccine Intravenously is impractical and potentially dangerous at scale. I work in an ER and it can easily take 20+ minutes to start an IV on a patient, especially if they're very young or very old. That's compared to administering Intramuscularly which will take 2 or 3 minutes at most. From what research we've done on vaccines, doing it intramuscularly is perfectly fine so there's just no reason to change that. There's also a greater risk of sepsis going from IM to IV since you're opening a path directly into your bloodstream instead of just near it (again I can't speak to whether or not the vaccine itself would cause issues, but I can't imagine it would help).

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