Recent comments in /f/askscience
[deleted] t1_j514y4s wrote
yerfukkinbaws t1_j514tql wrote
Reply to comment by beezlebub33 in Given that reproduction is difficult or impossible when both animals have different numbers of chromosomes, how did so many species evolve to have so many different numbers of them? by MercurioLeCher
> During reproduction, the chromosomes have to line up in order for them to produce offspring.
Just to be clear, chromosomes do not line up during reproduction. They only pair during meiosis, which is the production of sperm or eggs, but not during fertilization or embryonic development (mitosis). So chromosome number has absolutely zero effect on whether two individuals can produce offspring together, but may affect the fertility of their offspring.
This confusion over when chromosome pairing happens leads to a lot of the misconceptions around chromosome number.
HornedDiggitoe t1_j514owa wrote
Reply to comment by rm_systemd in Given that reproduction is difficult or impossible when both animals have different numbers of chromosomes, how did so many species evolve to have so many different numbers of them? by MercurioLeCher
Without food abundance none of that medicine would have helped much. All these medical marvels you brought up were invented after agriculture. Imagine what the life expectancy was for disabled/sick people prior to an abundance of food.
Also, 32 years old is old enough to have reproduced and pass on genes. Life expectancy was much lower prior to agriculture.
yerfukkinbaws t1_j513zuo wrote
Reply to comment by suvlub in Given that reproduction is difficult or impossible when both animals have different numbers of chromosomes, how did so many species evolve to have so many different numbers of them? by MercurioLeCher
The two unfused chromosomes from the parent with 46 will usually both pair with the fused chromosome that came from the parent with 44. This is called a trivalent, instead of the usual bivalent that forms in meiosis. The pairing actually usually goes just fine since the genetic content is not changed and these chhromosome fusions usually involve chromosomes that only had one arm before (acrosomes). What this means is that it's not as random as all that. There is still a chance that separating the chromosomes can go wrong, but the offspring of people who've had a fusion of this type are usually not infertile, just reduced fertility sometimes. Often not even by much and many, many cases are believed to be undiagnosed since there's no "symptoms."
[deleted] t1_j513oh8 wrote
Reply to comment by ChefArtorias in Is there any difference in efficacy when a vaccine is administered somewhere other than the upper arm (e.g. on the foot)? by MercurioLeCher
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off_the_cuff_mandate t1_j513a05 wrote
Reply to comment by Slashy1Slashy1 in Given that reproduction is difficult or impossible when both animals have different numbers of chromosomes, how did so many species evolve to have so many different numbers of them? by MercurioLeCher
If the 44 chromosome people survive though, it would likely be without procreating with 46 chromosome people, which would cause them to gradually adapt differently from the 46 chromosome people and eventually become a separate species.
xea123123 t1_j512xm9 wrote
Perhaps you almost saw a dozen birds die this week, but before death they became sickly and were picked off by predators. Perhaps others died right out in the open and were dragged off by scavengers before you saw them.
A dozen dead battery farmed chickens, on the other hand, would go nowhere and could likely infect many other chickens before being discovered counted and disposed of by a farm worker.
When my bird watcher friend finds dead birds on her hikes, she inspects them, then if they show signs of infection she bags and labels them to send to a research station. She's amazing at spotting a small dead bird in tall grass and I wouldn't have spotted any of the ones she did on our last hike.
[deleted] t1_j512o6u wrote
[deleted] t1_j512li5 wrote
Reply to comment by doaardvarksswim in How is protein folding quantum mechanical? by prionprion
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Weed_O_Whirler t1_j512ikh wrote
Reply to comment by -YellsAtClouds- in Whats stopping us from sending a probe into a black hole if we haven't already? by stealth941
The voyager spacecraft are well above the Solar escape velocity so they will be traveling on out of here.
Froggmann5 t1_j512hmv wrote
Reply to comment by WeaponizedKissing in What happens to the energy of sound in space? by full_hammer
There are toothbrushes like this that play the radio when you brush your teeth. If you put a wobbly fork to your teeth in space wouldn't you still hear it that way?
doaardvarksswim t1_j5124ad wrote
Reply to comment by smnms in How is protein folding quantum mechanical? by prionprion
Van-der-walls forces could not be more different from hydrogen bonding.
[deleted] t1_j511t7v wrote
-YellsAtClouds- t1_j511sis wrote
Reply to comment by Weed_O_Whirler in Whats stopping us from sending a probe into a black hole if we haven't already? by stealth941
Huh. So do you know if it will eventually slow all the way down, stop, and start returning towards the sun? Or will some other gravity source capture it before then?
[deleted] t1_j511k8c wrote
volyund t1_j5118c4 wrote
Reply to comment by Silverjeyjey44 in Is there any difference in efficacy when a vaccine is administered somewhere other than the upper arm (e.g. on the foot)? by MercurioLeCher
Because you don't want something immunogenic circulating in your bloodstream. That's how you get cytokine release syndrome, shock, and dead patients. You want localized immune reaction somewhere safe (like an arm), where immune cells can be recruited to from blood , tissue, or lymph; to do their thing.
[deleted] t1_j5112le wrote
Reply to comment by SaltyDangerHands in Whats stopping us from sending a probe into a black hole if we haven't already? by stealth941
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[deleted] t1_j510p6v wrote
Reply to comment by gwmccull in Is there any difference in efficacy when a vaccine is administered somewhere other than the upper arm (e.g. on the foot)? by MercurioLeCher
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docroberts t1_j510f46 wrote
Reply to comment by Slashy1Slashy1 in Given that reproduction is difficult or impossible when both animals have different numbers of chromosomes, how did so many species evolve to have so many different numbers of them? by MercurioLeCher
Fertility is one of many factors in the evolutionary equasion. In evolutionary time human populations have been very scattered At the center of a slightly isolated population this lineage reproduces normally. On the periphery of the isolated population there are more miscarriages, but adequate reproduction for introgression of useful genes into the population. It's probable Neandertal/Sapiens hybrids and Denisovan/Sapiens hybrids were significantly less fertile, yet their genes made it into our pool. Surprisingly the ancestral trees of individual genes are often very different than the species tree.
[deleted] t1_j510bsw wrote
Reply to How is protein folding quantum mechanical? by prionprion
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volyund t1_j510adm wrote
Reply to comment by seanmorris in Is there any difference in efficacy when a vaccine is administered somewhere other than the upper arm (e.g. on the foot)? by MercurioLeCher
Seriously?! I had no idea! Is there an article I can read on that? I've taken basic immunology, but that wasn't covered.
[deleted] OP t1_j51002k wrote
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dirtylostboy t1_j50zvi9 wrote
Reply to comment by Weed_O_Whirler in Whats stopping us from sending a probe into a black hole if we haven't already? by stealth941
But even if we had the speed, would anything survive passing through the kupiter belt or oort cloud? Or are they less dense with debri than I imagine?
volyund t1_j50zvb2 wrote
Reply to comment by Roadgoddess in Is there any difference in efficacy when a vaccine is administered somewhere other than the upper arm (e.g. on the foot)? by MercurioLeCher
Because you don't want inflammation response to vaccine speading through your blood stream and causing inflammation all over your body. That's how you get cytokine release syndrome, go into shock, and die.
You want a vaccine to cause a localized inflammation reaction (somewhere harmless, like an arm), recruit immune cells there, have them sample the antigen (vaccine), find ones that bind to the antigen, cause their proliferation, and as a result develop immunity to the disease. Your immune cells have a mechanism to be recruited out of the blood, lymph, and surrounding tissue and to get to the location of inflamation. Vaccination utilizes this mechanism. Vaccines are also specifically tested to work only through their specified method of administration, whether that's intramuscular (like most vaccines), nose spray (like flu mist), oral (like rotavirus), or skin administration (like BCG). Spraying regular flu vaccine into the nose won't work, just like giving it orally. It's formulated to elicit correct immune response only when it gets properly administered. The reason for this is more complex immunology.
ceelo71 t1_j5157gy wrote
Reply to comment by dryingsocks in Is there any difference in efficacy when a vaccine is administered somewhere other than the upper arm (e.g. on the foot)? by MercurioLeCher
That’s an interesting difference in practice. If a patient needs an IV bolus of a medication, does the physician also do that or is it delegated to a nurse?