Recent comments in /f/askscience

mutandis57 t1_jaq01xb wrote

Reply to comment by Ray_D_O_Dog in Could we enter a stable orbit of a black hole which enters the even horizon and comes back out? by Sol33t303

If the black hole is large enough (like the 4 million solar mass at our galaxy center), the point where tidal forces become unbearable lies way inside the event horizon. You could fall through the event horizon and not even notice unless paying attention to your navigation instruments. You'd continue to fall for the next 30 seconds blissfully unaware that there is now no chance to escape. You WILL get spaghettified in the last second before impact with the singularity though.

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the_fungible_man t1_japz7vm wrote

Reply to comment by RabbitFuzz in The Vyvanse patent expires this year. How long does it usually take generic alternatives to get approved, and how much of a reduction in cost is expected on average? by paleselan1

Following that link, it appears that the Vyvanse patents expired on February 24^th . It will be interesting to see whether and how quickly these other manufacturers are able to bring a generic to the market.

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RabbitFuzz t1_japxxdb wrote

Reply to The Vyvanse patent expires this year. How long does it usually take generic alternatives to get approved, and how much of a reduction in cost is expected on average? by paleselan1

It looks like there are a couple of companies that have applications in with the FDA for the generic version.

https://www.accessdata.fda.gov/scripts/cder/daf/index.cfm

Look up the generic name lisdexamfetamine and it has a couple of companies that have tentative approvals, like Actavis, Roxane, TEVA, Amneal, Myan, Sandoz and Norwich.

Even with approval, depending on the company, it might come out later or as others have mentioned, the company could sue others.

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iimplodethings t1_japxr4o wrote

Reply to Are the rocks and soil of other solid planets the same as the earth? by sudosudoku

I'm a physicist; you need a geologist or planetary scientist to really answer this. But from my very limited knowledge of planetary geology:

The minerals present on a planet depend a lot on what's going on inside the planet and how it formed. Planets with volcanic activity (e.g. Mars) will have igneous rocks whereas planets without probably won't; some minerals like olivine can be produced inside a planet but may chemically weather to other minerals depending on the atmosphere if there is any. But you find olivine on many planets and in meteorites, and it's the same mineral as the one you find on earth. Also some minerals need water to form - hydrated minerals found on mars can be indicators of past water in that area. Afaik the temperature (in the weather sense, not talking about volcanoes etc) in a region doesn't have much direct impact on minerals but can have a big impact on soils because it affects what life does, and that's the big uncertainty in your question about other planets. The "dirt" on earth is very different in a rainforest than in a desert largely because the rainforest dirt is full of living things and decaying organic matter, but the desert dirt is mostly mineral sand

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blackandgay676 t1_japvmhj wrote

Reply to The Vyvanse patent expires this year. How long does it usually take generic alternatives to get approved, and how much of a reduction in cost is expected on average? by paleselan1

The cost reduction part is highly dependent on the number of generic makers who want to get in.

I work in HIV prevention and the first generic of Truvada went from 2000 for brand name to ~1400 for generic because for the first 6 months there was only one generic drug maker. After those 6 months were up the price plummeted and I think now list price for it is anywhere from 30-100 bucks.

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Ray_D_O_Dog t1_japu3q1 wrote

Reply to Could we enter a stable orbit of a black hole which enters the even horizon and comes back out? by Sol33t303

I'm pretty sure that this is when you get "spaghettified."

Basically, the rate at which gravity changes (as a function of distance from the black hole) is so huge, that the gravitational force on your feet would be so much greater than that force on your head, that you would be stretched like taffy...or, um, spaghetti.

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ozwegoe t1_japram1 wrote

Reply to The Vyvanse patent expires this year. How long does it usually take generic alternatives to get approved, and how much of a reduction in cost is expected on average? by paleselan1

Depends. The manufacturer could sue or do something to put the patent in a holding pattern to extend the patent life until all legal issues are resolved.

But generally the generic will come out pretty quickly (especially if the manufacturer also makes generics).

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