Recent comments in /f/askscience
horyo t1_jbukcos wrote
Reply to comment by -Metacelsus- in What exactly is going on when a protein (or other molecule) binds with a receptor? by Eat-A-Torus
I find the lock and key mechanism to be a little bit more intuitive. A key (ligand) binds to the lock (protein/receptor) and a conformational change (unlocking) occurs.
For those other people who may also need ultra simplification.
Hk-Neowizard t1_jbujg5u wrote
Reply to When a wave travels goes from a higher impedance medium to a lower impedance medium, why would that cause a reflected wave? by agabwagawa
Here's an intuitive approach.
Consider the source of the vibrations in the middle of the medium. It's a combination of the inertia of the particle and the forces applied by neighboring particles.
When a particle at the boundary vibrates, the properties of the particle at the different medium applies a different force to the boundary particle. This changes the oscillation period of the boundary particle, which in turn applies a different force to the other particles in the original medium.
Essentially, the boundary particle goes out of sync, which reads as a reflection when scaled up to the entire boundary
Mathrinofeve t1_jbuiv2z wrote
Reply to Does having history of heat illness (especially heat stroke) make one’s body more sensitive to heat? by [deleted]
Heat stroke is caused by your body temperature being raised to a level that impacts its functions. Your body doesn’t build antibodies like it would against sickness and the human body has a safe temperature range it operates in.
So no having heat stroke years prior does not make you more likely to get it now.
[deleted] OP t1_jbuig8p wrote
[deleted] OP t1_jbuh7wr wrote
superbob201 t1_jbugnrs wrote
Reply to comment by agabwagawa in When a wave travels goes from a higher impedance medium to a lower impedance medium, why would that cause a reflected wave? by agabwagawa
No, for the same reason that going from low to high doesn't transmit all that energy into the pressure. Neither pressure nor motion can have a sudden discontinuous change.
hatsune_aru t1_jbuf38y wrote
Reply to comment by agabwagawa in When a wave travels goes from a higher impedance medium to a lower impedance medium, why would that cause a reflected wave? by agabwagawa
the energy doesn't just disappear, the reflected wave also carries some energy.
[deleted] OP t1_jbudqtw wrote
[deleted] t1_jbucxk8 wrote
Reply to comment by nanowell in Can long term cannabis abuse cause permanent changes to brain structure? by AlexMiles101
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operationarclightII t1_jbucuu4 wrote
Reply to comment by -Metacelsus- in What exactly is going on when a protein (or other molecule) binds with a receptor? by Eat-A-Torus
There have been updated models of receptor and ligand interaction. A big one that pharmacologists would point to is conformational selection, in which the receptor is constantly flipping between active, intermediate, and inactive states, even without a ligand. The presence of a ligand stabilizes the receptor into the active state until the ligand and receptor disassociate. There's a lot of cool quantum effects and such if you really get into the weeds with some of the PPI theories.
lernchecke t1_jbuca6e wrote
Reply to comment by -Metacelsus- in What exactly is going on when a protein (or other molecule) binds with a receptor? by Eat-A-Torus
Is a competetive inhibitor the same as a competetive antagonist?
[deleted] OP t1_jbubzi5 wrote
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[deleted] t1_jbuau8y wrote
Reply to comment by Hotdropper in What exactly is going on when a protein (or other molecule) binds with a receptor? by Eat-A-Torus
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[deleted] t1_jbu86q7 wrote
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Ridley_Himself t1_jbu8224 wrote
Yes. Radioactive decay can also be expressed by a decay constant, λ, which is effectively an instantaneous decay rate (relative to the amount present).
λ=ln(2)/t1/2.
It gets a bit more complicated with Y-90 since it is itself a decay product of Sr-90, so it will be produced at the same time it decays.
[deleted] OP t1_jbu80ue wrote
mikedensem t1_jbu7w6x wrote
Reply to comment by Thornwalker_ in What exactly is going on when a protein (or other molecule) binds with a receptor? by Eat-A-Torus
So, do most non-ligand molecules get kicked away due to a mismatch in bonding charges? How does the receptor repel other stuff?
slightofhand1 OP t1_jbu6e23 wrote
Reply to comment by Pikachorizo in If semaglutides just make you eat less, how can they not result in the same metabolic effects of weight loss via calorie restriction? by slightofhand1
So would the assumption be that losing weight via caloric restriction results in you producing less GLP-1 than normal? Which would explain how semaglutide induced weight loss doesn't?
slightofhand1 OP t1_jbu64pe wrote
Reply to comment by Jamesaliba in If semaglutides just make you eat less, how can they not result in the same metabolic effects of weight loss via calorie restriction? by slightofhand1
Also your body reacts to hunger by shutting down, so you start burning less and you plateau. This does not happen if instead of hunger you feel full. Semaglutide slows the food passing through you so you feel full
So the idea is that it somehow blocks whatever hormones or whatever tell your body that you're starving when you lose weight the old fashioned way?
[deleted] OP t1_jbu4inp wrote
[deleted] t1_jbu4diq wrote
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[deleted] t1_jbu4a10 wrote
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ahufflepuffhobbit t1_jbukiow wrote
Reply to Can long term cannabis abuse cause permanent changes to brain structure? by AlexMiles101
Several studies have linked marijuana consumption with the onset of schizophrenia and persistent psychotic symptoms. Some of these report that a frequent user of cannabis has 6 times higher probability of developing schizophrenia. This, however is neither a necessary or sufficient condition, there are other factors at play, some kind of genetic susceptibility being probably one of them.
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