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Thank you for posting sources.

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That first article (or the abstract at least) doesn't actually suggest this.

It shows people who have had heatstrokes are more susceptible to them. That's not the same as the previous heatstroke causing or contributing to their susceptibility.

Makes sense that people who were at higher risk already are more likely have had one in the past.

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Well when crashing into the planet yeah. Its gonna make a massive impact but orbiting the planet, no nothing will happen.

This makes a great deal of sense given that everything at that size/scale is moving and vibrating. Do you have a source for that model? I’d like to share with my students.

I cannot sweat, therefore, I'm very susceptible to heat-related illness. When I had my first heat stroke, the doctor said I'm more sensitive to heat now and need to be more mindful of my clothing choices, outside/indoor temperatures, monitor my body temperature, and always let any future doctor know about it because some medications can also cause a sensitivity/intolerance to heat.

This article from the '90s discusses the psychological and physiological effects of heat stroke.
This PDF discusses the thermal injuries of the nervous system after heat stroke.

I had no idea geneticists also did tiny code challenges, as well as programmers.

Though thinking about it, genetics is just soggy programming

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Because some clinical issues present as trauma informed, the results are clinically skewed in those studies. To find conclusively that any clinical issue can be created by environmental mechanics is redundant.

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It depends, but many chemical reactions are sensitive to orientation. Enzymes kind of guide the ligand in with a potential energy gradient, so it's not just a lock and key analogy, but more like a lock and a key, and a funnel for your drunk self to get the key into the keyhole at 2am

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This is the equivalent of a Republican saying “it’s snowing in Texas today so global warming isn’t real”.

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Repeated short term exposure to heat (without heat stroke) causes many of the same adaptations as exercise training including plasma volume expansion, improved cardiac output, decrease sweat sodium concentration, and increased thermoregulation capabilities. This makes a person less likely to suffer heatstroke.

I would imagine there could be permanent damage related to severe heat stroke, but I would be surprised if it made people more likely to suffer subsequent heat stroke (as one commenter liked to an article about). Anecdotally I know many people who’ve been hospitalized with heat stroke but have no issues in the heat subsequent to the initial incident

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So in that case, how critical is the positioning of the ligand and the receptor?

Going back to the lock and key analogy, sure, my key opens the lock, but only if it's inserted into the keyhole at a specific angle and orientation. I can't insert it backwards, or sideways, or even twisted a few degrees off axis and expect it to work.

If my key is subject to Brownian motion, even if there were m/b/tr-illions of them bouncing around outside the lock, I wouldn't expect one to fit within a given time frame.