Recent comments in /f/explainlikeimfive
Rahf t1_j2d6v85 wrote
Reply to comment by TheSaltySeagull1987 in ELI5 Why aren't we curing more degenerative diseases with stem cell research? by KaishiXYZ
A lot of research springs out of discovery from individual scientists, or small teams. These can then form a company in order to keep developing this drug or treatment, but will need to acquire funds and then drive the clinical pipeline with at least three major clinical trials.
Most so-called candidates you find in active clinical trials are always presenting themselves as a more effective way to treat a certain illness, or a completely new treatment for an illness that doesn't have effective cures or management therapies at this moment--there are many.
Each clinical trial can by itself take months or years to complete. That's not counting the preparatory work before as well as the complementary work after they finish. And this is assuming the company or group of people involved are constantly able to raise millions upon millions of dollars in capital to pay for this.
The big pharmaceutical companies draw benefit from their financial muscle, administrative power, and absolute knowledge on regulatory demands. So their pipelines are more streamlined, yet still take years upon years.
The Covid vaccines were extraordinary circumstances. They are not good examples of the timelines involved, because nearly every resource available was availed to that research and approval. Which meant everything else that was next in line got bumped down or to the side, and thus delayed.
Why does it take all this time? Because we have placed high demands on treatment being safe and effective, or at least not immediately dangerous to the patient.
FartyPants69 t1_j2d6v5p wrote
Reply to comment by vavverro in ELI5: How did we realise the mind is in the brain? by theembryo
Hmm, that's interesting but I don't know if that explains it exactly. I can recall being aware of the sensation of being "centered" in my head as a young child, long before I would have been aware of the physiology of my brain or nervous system.
Chickentrap t1_j2d6stk wrote
Reply to comment by Toffeemanstan in ELI5. Why is honey and lemon a popular cure for cold like symptoms. What makes lemon more effective than say an orange or lime? by alexkid_in_realworld
Ah the good old days of accidental infanticide through opium based medicines, makes you yearn for the simpler times.
avataraustin t1_j2d6ppr wrote
Consciousness is not entirely local to the brain. Search out numerous stories of people who have had out of body experiences.
Hyjynx75 t1_j2d6ff2 wrote
Reply to ELI5. Why is honey and lemon a popular cure for cold like symptoms. What makes lemon more effective than say an orange or lime? by alexkid_in_realworld
Unpasteurized honey has lots of proven health benefits. You can Google scientific studies that show this.
As for lemon or other citrus in tea, I couldn't find anything other than websites that sell tea telling me that lemon tea is amazing for my health. I suspect lemon is simply used as a low-calorie flavor/sweetener.
Drinking hot liquids when you have a cold can help to temporarily clear congestion.
FartyPants69 t1_j2d6b4m wrote
Reply to comment by Nooms88 in ELI5: How did we realise the mind is in the brain? by theembryo
And that makes intuitive sense, but why does that feeling persist when I'm lying in bed in a dark, quiet, still room? My senses are basically idling, very little input, but my "center" remains in my head. I think something has to account for that aside from sensory input.
rogue303 t1_j2d6b2p wrote
Reply to comment by lifesoidot in ELI5: How did we realise the mind is in the brain? by theembryo
Nope, he's probably talking about transcranial magnetic stimulation. You can use it to excite/suppress regions of the brain with interesting results.
Sjoerdiestriker t1_j2d60ef wrote
Reply to comment by morold in Eli5 How exactly does Noise cancellation work? That too in such small airbuds by Professional-Ad3441
Either that, or the quality of the noise reduction reduces. Imagine again playing a sound with throughs where the original sound had peaks and visa versa, but with a smaller magnitude than the original sound. Now the magnitude of the resulting wave will still be reduced, but not become exactly 0, so the noise cancellation will be imperfect
rabman123 t1_j2d5syu wrote
Reply to comment by Gman1111110 in ELI5: What are the pros and cons of the American sports franchise-based model? by [deleted]
But most American sports also come with good aspects like salary caps. An owner worth 20 billion won’t have a significant advantage over a team with an owner worth 3 billion. This system rewards good management and talent development since all teams are competing with similar financial limitations.
In European soccer the rich teams stay at the top because they can continually offer the largest contracts to the best players. If small clubs want to win and consistently compete at the top level, they can only hope to be bought by a rich sugar daddy. The pure capitalism of European soccer also kills competition. The financial gap between the top and bottom of the table is too massive to be fair by any stretch
vavverro t1_j2d5m6f wrote
Reply to comment by FartyPants69 in ELI5: How did we realise the mind is in the brain? by theembryo
Ancient Greeks and ancient Egyptians believed the heart was the source of thought, emotion, body control etc. it’s called cardiocentric theory. The fact that we feel our head to be the vessel of our consciousness is the result of scientific knowledge becoming common sense.
poundmastaflashd t1_j2d5ie6 wrote
Reply to comment by barrylunch in eli5 How does measuring area in square miles work? If you have very mountainous terrain, does that increase the area compared to somewhere that is very flat? by bluejeans90210
Nooo, man you have no IDEA about the kinda shit God can see. God's eye view is more like that scene at the end of Interstellar
vavverro t1_j2d5fft wrote
Reply to comment by EmilyU1F984 in ELI5: How did we realise the mind is in the brain? by theembryo
It’s a cultural thing. Not a “healthy human” thing. We think that way because it’s a common knowledge now, and feels self evident. Google cardiocentric theory. Ancient Egyptians and ancient Greeks believed that the source of thought and emotion was the heart, and that it controls movement.
Toffeemanstan t1_j2d5ck3 wrote
Reply to comment by spayder26 in ELI5. Why is honey and lemon a popular cure for cold like symptoms. What makes lemon more effective than say an orange or lime? by alexkid_in_realworld
Don't forget the morphine based cough medicines.
DomesticApe23 t1_j2d5cic wrote
Reply to comment by ColstonHowell in Eli5 what exactly causes the sensation of feeling thirsty when we are dehydrated? by crimeoutfit
When I get bored I go trawling for AI comments. This sub is heavily infected.
Adonis0 t1_j2d5c8a wrote
Reply to comment by krammark12 in ELI5: Why does putting one foot out from under the blankets bring so much relief of heat while laying in bed? by SirDuke6
Also, your foot is the furthest from your heart, and so cooling there helps it radiate a lot of heat from the body as in the return trip it cools your leg and torso a little
owen349 t1_j2d5bq7 wrote
Basically as your mouth opens your ears close.
A bit off topic but some bats use this to their advantage in that they can yell extremely loud (echlocation) but not become defined by the sound of their own screams.
Adonis0 t1_j2d59br wrote
Reply to comment by SirDuke6 in ELI5: Why does putting one foot out from under the blankets bring so much relief of heat while laying in bed? by SirDuke6
It’s perception
Your brain goes, I’m too hot right now but that will be fixed in a few moments so we’re going to make it feel fixed now so we don’t go overboard
If you only felt comfortable when everything was right you’d be stuck in a yo-yo of toss blankets off, get too cold, rug up, get too hot. So your brain makes it feel fine when you’ve done enough to fix it
wee-g-19 t1_j2d58cf wrote
Reply to ELI5: Why does putting one foot out from under the blankets bring so much relief of heat while laying in bed? by SirDuke6
I enjoy doing this it feels good. I work outside so most times wrap up warm, when overheating I pull my beanie up over my ears and I start to cool down without removing layers. Still warm I then roll up sleeves. Do whatever before removing a layer.
jpwanabe t1_j2d53it wrote
Reply to comment by nstickels in ELI5: Why does putting one foot out from under the blankets bring so much relief of heat while laying in bed? by SirDuke6
Holy shit. Did not know it moved that fast
TheArwingPilot t1_j2d5327 wrote
Reply to comment by grinning- in ELI5: How did we realise the mind is in the brain? by theembryo
I like this argument. I think what this argument is missing is the question of what the mind actually is and where i, the observer, the controller, the one thinking thoughts, exists while the brain is functioning normally.
ColstonHowell t1_j2d51pn wrote
Reply to comment by DomesticApe23 in Eli5 what exactly causes the sensation of feeling thirsty when we are dehydrated? by crimeoutfit
Seriously. Terrible answer and very clearly from ChatGPT or the like.
interstellargator t1_j2d4zog wrote
Reply to comment by qbookfox in ELI5: How did we realise the mind is in the brain? by theembryo
Do you interpret inner voice, thinking, and dreaming as occurring in the head because you innately know that's where it actually happens, or because you were told that's where it happens?
Plenty of emotions are felt in the chest. Excitement, love, despair, heartbreak. Seems just as reasonable to "intuitively know" that the soul lives in the heart or stomach.
just_push_harder t1_j2d4yql wrote
Reply to comment by morold in Eli5 How exactly does Noise cancellation work? That too in such small airbuds by Professional-Ad3441
Never thought about it, but yes, probably.
jezza129 t1_j2d4vrh wrote
To add onto what others have said, blu rays have more DRM, so the movie industry loves them. Playing a bluray on a PC can be a pain in the ass
Tobirama4374 t1_j2d6vta wrote
Reply to ELI5: Why does putting one foot out from under the blankets bring so much relief of heat while laying in bed? by SirDuke6
Coz they are literal heat sink. Think of hairless skin patches on body like foot soles, palms and facial area that don't grow hair as heat sinks in machine that need to throw away extra heat. Body is never not burning calories and thus constantly creates heat which is also why balls are outside so sperm don't die of heat.