dragononawagon OP t1_jdummdi wrote
Reply to comment by Sir_Vexer in Opposing retrograde and astrocyte-dependent endocannabinoid signaling mechanisms regulate lateral habenula synaptic transmission by dragononawagon
It doesn’t necessarily tell us that for sure, but it supports that hypothesis yes. And there’s some behavioral data out there from before this study to support the idea:
https://pubmed.ncbi.nlm.nih.gov/29887035/
But there’s also still the decrease in glutamate release in some contexts too. A lot more work has to be done to figure out what the 2 opposing systems are doing and how it ultimately could contribute to depressive-like behavior (or not).
Always take everything with a grain of salt (skepticism is part of good science), but there have been associations between chronic marijuana use and depression. Whether habenula is involved or not remains to be tested.
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