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dragononawagon OP t1_jdummdi wrote

It doesn’t necessarily tell us that for sure, but it supports that hypothesis yes. And there’s some behavioral data out there from before this study to support the idea:

https://pubmed.ncbi.nlm.nih.gov/29887035/

But there’s also still the decrease in glutamate release in some contexts too. A lot more work has to be done to figure out what the 2 opposing systems are doing and how it ultimately could contribute to depressive-like behavior (or not).

Always take everything with a grain of salt (skepticism is part of good science), but there have been associations between chronic marijuana use and depression. Whether habenula is involved or not remains to be tested.

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