Recent comments in /f/science

taphead739 t1_j6r30la wrote

Reply to Einstein’s theory helps to reveal Jupiter’s distant duplicate. A near-identical twin of Jupiter discovered around a distant star is the first planet to be found from space using a gravitational effect called microlensing. by MistWeaver80

Now hold up with the sensationalism. They found an exoplanet with 1.0-1.2 Jupiter masses using microlensing, which is cool. But that‘s all the info they have on the planet. Calling this a near-identical twin of Jupiter is like saying “I weigh 80kg and I found out someone in another part of the world weighs 88kg - that must be my near-identical twin!“

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kurt_go_bang t1_j6r1409 wrote

Reply to comment by Woodie626 in Endangered male northern quolls are giving up sleep in favour of having more sex – and it could be killing them, according to a study that investigated why male northern quolls usually mate themselves to death in one season while females can live and reproduce for up to four years. by MistWeaver80

I have heard of a vole. Always assumed it was similar to a mole. But not the quoll.

I do see the rhyming here though…..

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basmwklz OP t1_j6qziw7 wrote

Reply to The antidiabetic drug metformin aids bacteria in hijacking vitamin B12 from the environment through RcdA (Jan 2023) by basmwklz

Abstract: >Years of use of the antidiabetic drug metformin has long been associated with the risk of vitamin B12 (B12) deficiency in type 2 diabetes (T2D) patients, although the underlying mechanisms are unclear. Accumulating evidence has shown that metformin may exert beneficial effects by altering the metabolism of the gut microbiota, but whether it induces human B12 deficiency via modulation of bacterial activity remains poorly understood. Here, we show that both metformin and the other biguanide drug phenformin markedly elevate the accumulation of B12 in E. coli. By functional and genomic analysis, we demonstrate that both biguanides can significantly increase the expression of B12 transporter genes, and depletions of vital ones, such as tonB, nearly completely abolish the drugs’ effect on bacterial B12 accumulation. Via high-throughput screens in E. coli and C. elegans, we reveal that the TetR-type transcription factor RcdA is required for biguanide-mediated promotion of B12 accumulation and the expressions of B12 transporter genes in bacteria. Together, our study unveils that the antidiabetic drug metformin helps bacteria gather B12 from the environment by increasing the expressions of B12 transporter genes in an RcdA-dependent manner, which may theoretically reduce the B12 supply to T2D patients taking the drug over time.

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Reply to The antidiabetic drug metformin aids bacteria in hijacking vitamin B12 from the environment through RcdA (Jan 2023) by basmwklz

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Woodie626 t1_j6qz3qc wrote

Reply to comment by kurt_go_bang in Endangered male northern quolls are giving up sleep in favour of having more sex – and it could be killing them, according to a study that investigated why male northern quolls usually mate themselves to death in one season while females can live and reproduce for up to four years. by MistWeaver80

Surly you've heard of the Vole? They rhyme with Quoll, and the males seem to die in the same manner.

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