Recent comments in /f/science

Dumguy1214 t1_j7aipm1 wrote

Reply to comment by GGG_Eflat in A new study suggests that too much screen time during infancy may lead to changes in brain activity, as well as problems with executive functioning — the ability to stay focused and control impulses, behaviors, and emotions — in elementary school. by Wagamaga

I saw a guy on tv the other day and he talked about walking into a school and it was dead silent with the kids holding there phones like heroin addicts

he then walked into a school that had banned phones, kids talking and screaming, playing around

I am 43, I use my phone to call and play music

3

Ecyclist t1_j7a83gq wrote

Reply to New study links psychedelic drug experience to certain positive health behaviors - A new online survey of U.S. adults indicates that people who report using any of the classic psychedelics at least once in their lives also reported smoking cigarettes less often and eating healthier diets. by mossadnik

I once did shrooms and threw up the McDonald’s I ate earlier that day. I didn’t have a scale and assumed the 20 shrooms in the bag were meant to be eaten all at once. I was tripping hard for 30 hours straight. One of the longest fasts of my life.

Also my lighter had been using beforehand, had a picture of the spider on a side of it. Why gas stations sell lighters like that are beyond me. But at the time, I was absolutely terrified of the spider sitting on my lighter, so I didn’t have a cigarette for an entire day.

So I guess you could say, I was much healthier after that.

14

basmwklz OP t1_j7a7om4 wrote

Reply to FMO rewires metabolism to promote longevity through tryptophan and one carbon metabolism in C. elegans (Feb 2023) by basmwklz

Abstract: >Flavin containing monooxygenases (FMOs) are promiscuous enzymes known for metabolizing a wide range of exogenous compounds. In C. elegans, fmo-2 expression increases lifespan and healthspan downstream of multiple longevity-promoting pathways through an unknown mechanism. Here, we report that, beyond its classification as a xenobiotic enzyme, fmo-2 expression leads to rewiring of endogenous metabolism principally through changes in one carbon metabolism (OCM). These changes are likely relevant, as we find that genetically modifying OCM enzyme expression leads to alterations in longevity that interact with fmo-2 expression. Using computer modeling, we identify decreased methylation as the major OCM flux modified by FMO-2 that is sufficient to recapitulate its longevity benefits. We further find that tryptophan is decreased in multiple mammalian FMO overexpression models and is a validated substrate for FMO-2. Our resulting model connects a single enzyme to two previously unconnected key metabolic pathways and provides a framework for the metabolic interconnectivity of longevity-promoting pathways such as dietary restriction. FMOs are well-conserved enzymes that are also induced by lifespan-extending interventions in mice, supporting a conserved and important role in promoting health and longevity through metabolic remodeling.

8

AutoModerator t1_j7a7nfy wrote

Reply to FMO rewires metabolism to promote longevity through tryptophan and one carbon metabolism in C. elegans (Feb 2023) by basmwklz

Welcome to r/science! This is a heavily moderated subreddit in order to keep the discussion on science. However, we recognize that many people want to discuss how they feel the research relates to their own personal lives, so to give people a space to do that, personal anecdotes are allowed as responses to this comment. Any anecdotal comments elsewhere in the discussion will be removed and our normal comment rules apply to all other comments.

I am a bot, and this action was performed automatically. Please contact the moderators of this subreddit if you have any questions or concerns.

1

zeebette t1_j7a5ptm wrote

Reply to comment by [deleted] in A new study suggests that too much screen time during infancy may lead to changes in brain activity, as well as problems with executive functioning — the ability to stay focused and control impulses, behaviors, and emotions — in elementary school. by Wagamaga

They wanted to give my 4 year old an iPad in TK. An iPad to a 4 year old for school to take home. Absolutely not. Use it at school or whatever but she is not bringing that home.

I can only surmise that they, teachers and school districts, are giving children these devices in class to be used in a similar way that parents are using them, but using the word “educational” in front of the words “games” and “videos” to justify their use. But let’s only blame and shame parents and make no mention of that at all.

Not saying that this study was doing that- they actually seemed to recognize the value of screen time to parents, but a lot of the discussion around this topic in general comes off as very judgmental. I got 4 young kids and no gated off outside space. Come at me with solutions for evening time.

4