ffs is that what was causing my itching? I was having kidney trouble for years, and every night i had the worst itch on my back. It got to the point where I kept a pair of scissors by the bed and used them to scrape the itch (longwise against the flat edge).

15 minutes of yoga a day could do it for you

The opposite actually - the genetic predisposition for mental illness can’t weed itself out of the population unless it onsets before being passed on. If the predisposition is passed on and then fully manifests, then there’s a scenario where offspring grow up with both the genetic predisposition and in potentially a less-optimal environment resulting from the parent’s mental illness

"prehistoric penguins’ humongous humerus"

Science brings us advanced tongue twisters.

Like comparing greenhouse tomatoes with homegrown tomatoes.

And less less than 1% of them were killed by humans.

Glancing at the abstract as I don't access to the full article, but this study's population was very specific - "patients with extremity fractures that had been treated operatively or with any pelvic or acetabular fracture".

It would be interesting to see if aspirin continued to be noninferior in patients with conditions that were even more procoagulable, such as sepsis or covid. Does anyone happen to know if this is an active area of research being investigated in another conditions?

Why does everyone only talk about low dose aspirin regiments rather than just normal/higher dose aspirin for more serious cases?

That's very interesting, thanks for sharing! I would be interested to see if this is related to autophagy modulation and oxidative stress given that prolonged periods of feast vs. fast may result in lower cellular turnover, and as a result, higher incidence of mutation, degradation, and greater levels of stored toxins.

Anecdotal evidence suggests intermittant and medium-term fasting promotes not only autophagy in general, but release and processing of toxins from freed lipids with ketosis. With more new cells, less malformed or damaged DNA should be present, so would that affect the DunedinPACE DNAm algorithm? For those with more time and interest, I noticed some relevant sources cited at the bottom of the report. Of particular interest are the ones regarding telomeres, the validity of the different DNAm clocks, and intermittant fasting.

A while ago I saw an interview with a group of seniors who practiced calorie restriction for health reasons. They all moved and spoke like they lacked energy and looked generally miserable though that might have been the upper middle-class snobbery.

Given the poor quality of most Western diets which have been well established as conducive to inflammatory diseases, the results of this study might be a good example of correlation not indicating causation. Eating less food might improve health because of a reduction in inflammation caused by a poor quality diet, not necessarily because less calories are consumed. To my knowledge, calorie restriction has not been associated with longevity or any positive health outcomes in so-called blue zones:

https://en.wikipedia.org/wiki/Blue_zone#/media/File:3_blue_zones_venn_diagram.svg

We're at a point where we know what leads to healthy, long lives, there's no need to rewrite the alphabet in that sense, or more precisely, to eat less calories than we should, we simply need to restructure society so that we can practice what we know is good for us.

Yeah... but it spreads like a weed and needs to be controlled. Can be pretty invasive in a ton of places.

Bugs and humidity are then an issue.

Sorry; I'll take my barely weaker indoor bug, insecticide and mold free weed. Also; we'll figure this out. Indoor growers have advanced the plant a century inside of 20 years.

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The big question is an aspirin regiment as effective as Eliquis?

Eliquis has the most total cost the U.S. government, nearly $10 billion in 2020, not to mention its extreme cost for patients.

If low dose aspirin is as effective it will save a boatload of cash for both the government and for patients.

Abstract: >The geroscience hypothesis proposes that therapy to slow or reverse molecular changes that occur with aging can delay or prevent multiple chronic diseases and extend healthy lifespan1,2,3. Caloric restriction (CR), defined as lessening caloric intake without depriving essential nutrients4, results in changes in molecular processes that have been associated with aging, including DNA methylation (DNAm)5,6,7, and is established to increase healthy lifespan in multiple species8,9. Here we report the results of a post hoc analysis of the influence of CR on DNAm measures of aging in blood samples from the Comprehensive Assessment of Long-term Effects of Reducing Intake of Energy (CALERIE) trial, a randomized controlled trial in which n = 220 adults without obesity were randomized to 25% CR or ad libitum control diet for 2 yr (ref. 10). We found that CALERIE intervention slowed the pace of aging, as measured by the DunedinPACE DNAm algorithm, but did not lead to significant changes in biological age estimates measured by various DNAm clocks including PhenoAge and GrimAge. Treatment effect sizes were small. Nevertheless, modest slowing of the pace of aging can have profound effects on population health11,12,13. The finding that CR modified DunedinPACE in a randomized controlled trial supports the geroscience hypothesis, building on evidence from small and uncontrolled studies14,15,16 and contrasting with reports that biological aging may not be modifiable17. Ultimately, a conclusive test of the geroscience hypothesis will require trials with long-term follow-up to establish effects of intervention on primary healthy-aging endpoints, including incidence of chronic disease and mortality18,19,20.

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Not to mention lead paint poisoning

Introvert weed vs extrovert weed

Original study: Hunting and processing of straight-tusked elephants 125.000 years ago: Implications for Neanderthal behavior

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I don't think we even have figured out all the different cannabinoids yet so don't bet on that just yet. We also are only now just starting to understand study the endocannabinoid systems in humans.

But the entire organism is connected and affecting one system could presumably affect the plant's ability to create certain molecules over others. I'm not saying this is the case, but good experiments should control for as many variables as possible, especially something as simple as the growth medium of the plants.

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