Recent comments in /f/science

MushroomNovaCat t1_j7w9959 wrote

Reply to comment by radischen2 in Effect of long-term caloric restriction on DNA methylation measures of biological aging in healthy adults from the CALERIE trial (Feb 2023) by basmwklz

Because the diets of the participants were not analyzed, only a caloric deficit was tracked, and the results therefore can't be used to claim that sustained caloric restriction itself is a necessary predictor of better health outcomes. Someone eating an appropriate amount of calories from a good diet might have the same or better health than someone eating an unhealthy calorie restricted Western diet. In other words, it's not necessary to eat less calories than recommended to be healthy, calorie restriction is not practiced in areas known for health and longevity. There are various factors that go into good health and a long life that have been identified in blue zones but calorie restriction is not one of them.

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Pro-Karyote t1_j7w865m wrote

Reply to comment by TinFoilHeadphones in According to a study on 12,211 patients, aspirin is just as effective at preventing blood clots as low molecular weight heparin, but it costs less and is easier to administer by giuliomagnifico

For daily prophylactic use, it’s 81mg for all body weights (though the actual definition of low-dose aspirin is anything less than 100mg per day - 81mg is traditionally the dose for historical reasons).

Current Aspirin Guidelines

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jeronimoe t1_j7w7dpp wrote

Reply to comment by Pleasant__Bumblebee in Researchers Block Allergic Reactions to Peanuts in Mice – In an important first step to protect against peanut allergies in humans, researchers used a first-in-class allergen-specific inhibitor to prevent allergic reactions in humanized mouse models. by swhelan_tn

I would love to visit all these countries in Asia but with all the peanuts and the language barrier I'm too afraid to go.

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jomosexual t1_j7w74fu wrote

Reply to Researchers Block Allergic Reactions to Peanuts in Mice – In an important first step to protect against peanut allergies in humans, researchers used a first-in-class allergen-specific inhibitor to prevent allergic reactions in humanized mouse models. by swhelan_tn

I have a general allergy to most fruits in vegetable in different forms. Also constant pollen and dust allergy. Its probably a mild immune disease but if I could take a pill to just stop it I would try a banana or have a papaya salad

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Pleasant__Bumblebee t1_j7w686m wrote

Reply to comment by almostcyclops in Researchers Block Allergic Reactions to Peanuts in Mice – In an important first step to protect against peanut allergies in humans, researchers used a first-in-class allergen-specific inhibitor to prevent allergic reactions in humanized mouse models. by swhelan_tn

Damn, I feel for her. Luckily I'm ok to smell it and only have a minor reaction. And it's pretty easy to avoid as long as you take some basic precautions. Fish I can't even imagine. Not even sushi...

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Pro-Karyote t1_j7w5lvw wrote

Reply to comment by rdizzy1223 in According to a study on 12,211 patients, aspirin is just as effective at preventing blood clots as low molecular weight heparin, but it costs less and is easier to administer by giuliomagnifico

Largely because there isn’t an increase in efficacy for higher doses of aspirin for prevention of cardiac or stroke events, but there is an increased risk of bleeding events with increasing doses according to several studies.

Effects of Aspirin Dose When Used Alone or in Combination With Clopidogrel in Patients With Acute Coronary Syndromes

Double-dose versus standard-dose clopidogrel and high-dose versus low-dose aspirin in individuals undergoing percutaneous coronary intervention for acute coronary syndromes (CURRENT-OASIS 7): a randomised factorial trial

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pokey1984 t1_j7w5akn wrote

Reply to comment by rdizzy1223 in According to a study on 12,211 patients, aspirin is just as effective at preventing blood clots as low molecular weight heparin, but it costs less and is easier to administer by giuliomagnifico

Because "more aspirin" doesn't thin the blood any more than a low dose.

After 81 mgs, you don't see any increase in the amount it thins the blood and higher doses over extended periods can be hard on the stomach and kidneys.

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almostcyclops t1_j7w3o4f wrote

Reply to comment by Pleasant__Bumblebee in Researchers Block Allergic Reactions to Peanuts in Mice – In an important first step to protect against peanut allergies in humans, researchers used a first-in-class allergen-specific inhibitor to prevent allergic reactions in humanized mouse models. by swhelan_tn

I know right? My spouse has a fish allergy. Not as immediately deadly as most peanut allergies but just from being near it she can still get swelling, irritation, and in extreme cases throat closing. She can't eat certain foods at many restaurants, cant eat at all at certain resteraunts, can't even go in some grocery stores or even walk down certain streets in bad areas. But we live in the Pacific Northwest so it's everywhere. Could we visit Japan? Probably not. Could we visit London? No idea. Fish and chips are popular there but I just don't know if its popular enough that you can smell it in the air.

Hopefully this kind of research continues to make breakthroughs for all allergies.

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