Recent comments in /f/science

SodaRayne t1_j7wpb7g wrote

> DVT and PE.

Deep Vein Thrombosis and Pulmonary Edema?

edit: That's what I get for reading the comments before the article. Deep venous thromboembolism (DVT) is listed in the first sentence.

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Pro-Karyote t1_j7wp06j wrote

It has to do with a unit of measurement we don’t currently use for dosing medications, called a grain. The full dose of aspirin was 5 grains, which is about 325mg. The low dose was a quarter of the full dose, so 1.25 grains (which is roughly 81mg). That was the dose that was on formulary, and since it falls within the low-dose range and it was the dose available, it stuck.

Brief overview of aspiring dosing history

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aedes t1_j7wnkhn wrote

Non-inferior is not “just as effective.” That would require an equivalence study to conclude, rather than a non-inferiority study.

Rather, a positive non-inferiority like this best interpreted as “aspirin is tolerably close to low-molecular weight heparin.”

Where the researchers have defined what “tolerably close” means. It could very well be 10% worse than low-molecular weight heparin. But if the non-inferiority margin was set to 15%, the study would conclude that aspirin was non-inferior.

You can’t interpret non-inferiority study results without knowing the non-inferiority margin and how it was derived and if it seems to be a reasonable amount or not.

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newpsyaccount32 t1_j7wn87z wrote

first, i'd like to state that i fully agree with you.

second, i'd guess that they did this because these differences are typical to most grow situations. lots of guys growing outside prefer to use soil and compost tea. lots of guys growing inside prefer some sort of media blend with bottled nutes.

basically, these are two opposite ends of the growing spectrum. still, the fact that they did not control all possible variables means that this study is useless for comparing sunlight vs lights.

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AnnexBlaster t1_j7wmgtr wrote

Yes I do research on the effects of anticoagulant drugs for sepsis, but I haven’t investigated aspirin yet, I suspect though that the toxins in sepsis cause far too much platelet activation for aspirin to handle, ticagrelor on the other hand looks very promising for increasing platelet killing efficiency and host survival.

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ohgoshyes t1_j7wldwl wrote

you’re joking ? do u know how bright the sun is? you should go check out Bruce Bugbee and his research on cannabis. i thought i knew something. no lights are even close to the sun nor the wave lengths nor spectrum. check out his grow light myths video it will change your perspective

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NotAnotherEmpire t1_j7wj92d wrote

Question: They say that

"In the CALERIE Trial, the %CR achieved by participants in the treatment group varied, with most participants achieving doses below the prescribed 25% (mean = 11.9)"

This seems to indicate this is not being achieved by a standardized diet. They're hitting varied reductions and most are off by 200+ calories. Wouldn't that raise some confounding issues? If the cut is hard to achieve, the fastest ways to do it are dropping junk food and calorie heavy drinks.

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