Recent comments in /f/science
Km2930 t1_j7wrudv wrote
Reply to comment by Pandoras_Cockss in According to a study on 12,211 patients, aspirin is just as effective at preventing blood clots as low molecular weight heparin, but it costs less and is easier to administer by giuliomagnifico
No, the question is, which one leads to more bleeding.
arborite t1_j7wqas6 wrote
Reply to comment by newpsyaccount32 in Researchers find that outdoor cannabis can "express more cannabinoids with potentially desirable bioactivity" compared to cannabis cultivated indoors under artificial lights. by OregonTripleBeam
That's true but showing differences exist at all allows them to request additional funding to separate out the variables.
SodaRayne t1_j7wpb7g wrote
Reply to comment by sciolycaptain in According to a study on 12,211 patients, aspirin is just as effective at preventing blood clots as low molecular weight heparin, but it costs less and is easier to administer by giuliomagnifico
> DVT and PE.
Deep Vein Thrombosis and Pulmonary Edema?
edit: That's what I get for reading the comments before the article. Deep venous thromboembolism (DVT) is listed in the first sentence.
Pro-Karyote t1_j7wp06j wrote
Reply to comment by tjeulink in According to a study on 12,211 patients, aspirin is just as effective at preventing blood clots as low molecular weight heparin, but it costs less and is easier to administer by giuliomagnifico
It has to do with a unit of measurement we don’t currently use for dosing medications, called a grain. The full dose of aspirin was 5 grains, which is about 325mg. The low dose was a quarter of the full dose, so 1.25 grains (which is roughly 81mg). That was the dose that was on formulary, and since it falls within the low-dose range and it was the dose available, it stuck.
[deleted] t1_j7worws wrote
[deleted] t1_j7woby3 wrote
AnnexBlaster t1_j7wo9p3 wrote
Reply to comment by odoroustobacco in According to a study on 12,211 patients, aspirin is just as effective at preventing blood clots as low molecular weight heparin, but it costs less and is easier to administer by giuliomagnifico
Bro its aspirin at 1/3 dose twice a say
[deleted] t1_j7wo390 wrote
Jigglysquare t1_j7wnuc6 wrote
Reply to comment by pokey1984 in According to a study on 12,211 patients, aspirin is just as effective at preventing blood clots as low molecular weight heparin, but it costs less and is easier to administer by giuliomagnifico
"Heparin" and "low molecular weight heparin" are also different.
aedes t1_j7wnkhn wrote
Reply to According to a study on 12,211 patients, aspirin is just as effective at preventing blood clots as low molecular weight heparin, but it costs less and is easier to administer by giuliomagnifico
Non-inferior is not “just as effective.” That would require an equivalence study to conclude, rather than a non-inferiority study.
Rather, a positive non-inferiority like this best interpreted as “aspirin is tolerably close to low-molecular weight heparin.”
Where the researchers have defined what “tolerably close” means. It could very well be 10% worse than low-molecular weight heparin. But if the non-inferiority margin was set to 15%, the study would conclude that aspirin was non-inferior.
You can’t interpret non-inferiority study results without knowing the non-inferiority margin and how it was derived and if it seems to be a reasonable amount or not.
[deleted] t1_j7wndjm wrote
newpsyaccount32 t1_j7wn87z wrote
Reply to comment by A_Swayze in Researchers find that outdoor cannabis can "express more cannabinoids with potentially desirable bioactivity" compared to cannabis cultivated indoors under artificial lights. by OregonTripleBeam
first, i'd like to state that i fully agree with you.
second, i'd guess that they did this because these differences are typical to most grow situations. lots of guys growing outside prefer to use soil and compost tea. lots of guys growing inside prefer some sort of media blend with bottled nutes.
basically, these are two opposite ends of the growing spectrum. still, the fact that they did not control all possible variables means that this study is useless for comparing sunlight vs lights.
-businessskeleton- t1_j7wmyzq wrote
Reply to comment by Pleasant__Bumblebee in Researchers Block Allergic Reactions to Peanuts in Mice – In an important first step to protect against peanut allergies in humans, researchers used a first-in-class allergen-specific inhibitor to prevent allergic reactions in humanized mouse models. by swhelan_tn
We're so we sign up?
[deleted] t1_j7wmx0g wrote
Throwforventing t1_j7wmjje wrote
As someone without this condition, but with very sensitive skin that itches frequently, I really feel for all of you that suffer from this. I can't imagine.
Although sometimes I will rub my back against the wall like a bear.
AnnexBlaster t1_j7wmgtr wrote
Reply to comment by Hapgam in According to a study on 12,211 patients, aspirin is just as effective at preventing blood clots as low molecular weight heparin, but it costs less and is easier to administer by giuliomagnifico
Yes I do research on the effects of anticoagulant drugs for sepsis, but I haven’t investigated aspirin yet, I suspect though that the toxins in sepsis cause far too much platelet activation for aspirin to handle, ticagrelor on the other hand looks very promising for increasing platelet killing efficiency and host survival.
HenryKrinkle t1_j7wm3la wrote
Reply to comment by sciolycaptain in According to a study on 12,211 patients, aspirin is just as effective at preventing blood clots as low molecular weight heparin, but it costs less and is easier to administer by giuliomagnifico
Boneitis strikes again
[deleted] t1_j7wlpna wrote
ohgoshyes t1_j7wldwl wrote
Reply to comment by ryanjovian in Researchers find that outdoor cannabis can "express more cannabinoids with potentially desirable bioactivity" compared to cannabis cultivated indoors under artificial lights. by OregonTripleBeam
you’re joking ? do u know how bright the sun is? you should go check out Bruce Bugbee and his research on cannabis. i thought i knew something. no lights are even close to the sun nor the wave lengths nor spectrum. check out his grow light myths video it will change your perspective
tjeulink t1_j7wl80m wrote
Reply to comment by Pro-Karyote in According to a study on 12,211 patients, aspirin is just as effective at preventing blood clots as low molecular weight heparin, but it costs less and is easier to administer by giuliomagnifico
Historical reasons on medicine dosages? Now im interested haha
Redditcommentorsrdum t1_j7wk87o wrote
Reply to According to a study on 12,211 patients, aspirin is just as effective at preventing blood clots as low molecular weight heparin, but it costs less and is easier to administer by giuliomagnifico
Sponsored by aspirin manufacturers
Here4Headshots t1_j7wjuch wrote
Reply to Effect of long-term caloric restriction on DNA methylation measures of biological aging in healthy adults from the CALERIE trial (Feb 2023) by basmwklz
Smart ppl who've read the link. Yes or no?
NotAnotherEmpire t1_j7wj92d wrote
Reply to Effect of long-term caloric restriction on DNA methylation measures of biological aging in healthy adults from the CALERIE trial (Feb 2023) by basmwklz
Question: They say that
"In the CALERIE Trial, the %CR achieved by participants in the treatment group varied, with most participants achieving doses below the prescribed 25% (mean = 11.9)"
This seems to indicate this is not being achieved by a standardized diet. They're hitting varied reductions and most are off by 200+ calories. Wouldn't that raise some confounding issues? If the cut is hard to achieve, the fastest ways to do it are dropping junk food and calorie heavy drinks.
ryanjovian t1_j7wj5rj wrote
Reply to comment by ohgoshyes in Researchers find that outdoor cannabis can "express more cannabinoids with potentially desirable bioactivity" compared to cannabis cultivated indoors under artificial lights. by OregonTripleBeam
The indoor growing process does exactly that to increase potency and density. So in this specific case we have not only replicated but improved upon the sun.
skoolofphish t1_j7wt0tk wrote
Reply to Researchers find that outdoor cannabis can "express more cannabinoids with potentially desirable bioactivity" compared to cannabis cultivated indoors under artificial lights. by OregonTripleBeam
Yeah if you've ever had fresh outdoor stuff directly from the farm in Mendocino county you know whats up. Although there's nothing wrong with indoor stuff either!