Recent comments in /f/science

Wagamaga OP t1_j7ysg2f wrote

About 250 million years ago, the Permian-Triassic mass extinction killed over 80 per cent of the planet's species. In the aftermath, scientists believe that life on earth was dominated by simple species for up to 10 million years before more complex ecosystems could evolve. Now this longstanding theory is being challenged by a team of international researchers – including scientists from McGill University and Université du Québec à Montréal.

A fossilized ocean ecosystem Until now, scientists have long theorized that scorching hot ocean conditions resulting from catastrophic climate change prevented the development of complex life after the mass extinction. This idea is based on geochemical evidence of ocean conditions at the time. Now the discovery of fossils dating back 250.8 million years near the Guizhou region of China suggests that complex ecosystems were present on Earth just one million years after the Permian-Triassic mass extinction, which is much earlier than previously thought

https://www.science.org/doi/10.1126/science.adf1622

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Sgt_Munkey t1_j7yq5vp wrote

Just recovering from a smashed ankle and have to inject dalteparin daily. I hate needles, and wish this was prescribed instead... Perhaps it may be useful for a period of time when my lmwh course ends if I'm still stuck in bed elevating my leg...

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YepYep123 t1_j7yfg7i wrote

It’s important to look at what they define as their primary outcome.

Aspirin was non-inferior to LMWH when it came to death from any cause. However, the rates of venous thrombosis (which is what ASA and LMWH are trying to prevent) was higher in the aspirin group. It was only 0.8% higher, though in a study of over 12 000 patients that equates to an extra 1000 people getting a blood clot and this was statistically significant.

While these blood clots may not have increased mortality, that doesn’t mean they have no morbidity. Patients can get chronic symptoms of swelling and pain after a DVT (called post thrombotic syndrome). This is reported in around 20-50% of patients with DVT, so conservitavely 200 people on the study are likely to have long term symptoms (often lifelong) as a result of being randomized to aspirin. While more rare, there is also risk of cardiac and lung complications after a pulmonary embolism (such as pulmonary hypertension) which can be quite severe.

At my hospital, nearly all patients are on LMWH for VTE prevention and complications from this are exceedingly rare. If it were me in hospital with a fracture, I’d take LMWH over ASA any day.

Source: Hematologist who sees people on blood thinners every working day.

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AnnexBlaster t1_j7yevf3 wrote

Theres proteins in Staph aureus called clumping factors which active platelets, and pore forming exotoxins called alpha hemolysins which cause major damage.

Sepeis varies a great deal between bacteria, the toxins from different pathogens determine whether your immune system will win, or how fast and painful your death will be

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dumbest_smartass t1_j7y7u8b wrote

:( I miss the pain meds that work best for me. Mmj made life manageable. Especially parenthood as a single parent, it made my chronic pain almost nonexistent with the presence of my child. (Never consumed in the same vicinity or while child was awake or able to smell or see it, before the mombies and other undesirables try piping in.)

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BuggerMyElbow t1_j7y68tl wrote

What are the toxins involved in sepsis and where do they come from?

I'd imagine they come from the bacteria, so lipopolysaccharides/endotoxin? Are these responsible for platelet malfunction?

Also how does sepsis vary depending on the species and strain of bacteria?

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zero0n3 t1_j7y4y29 wrote

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