They can when federally legal. But why enter in a new market when the one youre in is taking in truckloads of cash?

This one is conducted in mice.

But this could be a trailhead for finding a treatment.

We are not new. In the words of Picasso, “we have invented nothing”

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I'll also add that we don't see the mood and cognitive effects of caloric restriction monitored in these studies. We already have several studies demonstrating that "hangryness" is real and has negative effects on mood and cognition which once again, circles back to my original comment. Just because we can recognize the benefits of certain practices even if we don't precisely understand them doesn't mean that those practices are sustainable or that they don't affect other areas negatively.

I don't see any diet specifics listed. As I said, fiber is given to animals to account for the missing calories in these studies and we already know that fiber has beneficial effects on health, as was pointed out by this study.

My god I’m sorry.

But handjob study to see if they could induce neuropathic addiction response.

My brain instantly went there for some reason. It’s been a long week.

Friendly reminder than less calories doesn't imply less volume. I love grapefruit, berries, air popped popcorn, boiled potatoes, brussels sprouts and snack on them frequenly. Just look for food that is very filling for the ammount of cals

I would love to participate in one of these studies

So long as we have liquid water, life will spin up. It's a perfect medium for simple chemistry to coalesce, a critical point for formation.

Diet composition compared to energy intake has also been investigated in animals. Read the introduction to the linked study and the authors discuss previous findings demonstrating CR working independently from diet composition.

“We recently completed a longitudinal study in male C57BL/6J mice (B6) initiated at 4 months of age in which the effects of the two diet compositions under ad libitum (AL) and CR conditions were measured (Mitchell et al., 2019). Independent of diet, male B6 mice on 30% CR exhibited significant improvements in health, survival, and a delayed onset of cancer with respect to AL-fed mice.”

https://www.sciencedirect.com/science/article/pii/S1550413120302357

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I wonder where humanity will be in 1 million years

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This particular study did not monitor diet so no, that question has not been answered. It's not understood why caloric restriction improves health and longevity, there are various competing theories which were outlined in a study someone else linked in a comment.

It doesn't get rid of the pain exactly, it just makes it feel good, if that makes sense.

Not necessarily, the reason being that animals are fed more fiber to keep them from being hungry in these studies and we already know that fiber is beneficial to health.

Even if you don't live longer, it will feel longer.

Eww. You're still a six percenter, which is far from normal.

Yeah "activated during" is very far from "responsible for." This is a correlational finding - which is valuable, but should not be communicated as having a particular direction or causality.

Edit: the study itself uses the phrase "involved in"

2.9 million years ago hunting hippos with sticks and stones was not for a faint of heart. I respect our ancestors more with each new learning.

But:

https://www.nature.com/articles/s41569-018-0072-2

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This is Reddit, where is the tldr bot?