Recent comments in /f/science

randompersonx t1_j88fauu wrote

Reply to comment by crazyhadron in Metformin regulates myoblast differentiation through an AMPK-dependent mechanism (Feb 2023) by basmwklz

Keep track of AST/ALT over time. Part of how Metformin works is it blocks gluconeogenesis which is basically the process of the liver producing glucose. Most likely if you are relatively low body fat % and have hopefully zero (or very low) visceral body fat, this may not matter so much…

But I’d imagine the higher risk comes into play if you have a NAFLD already.

And yes, you are right about kidney issues, too. My dad was on Metformin for a few years and was eventually diagnosed with some mild kidney issues that were believed to be caused by it, and his medications were changed. That said, my dad is overweight and inactive and diabetic… so his case will be very different if you are living a healthy lifestyle.

4

Dragonpuke56 t1_j88efu2 wrote

Reply to comment by PMzyox in Large study provides evidence that goal incongruence can harm romantic relationship satisfaction by glum-platimium

There's a lot of theatrics going on with others that "make it easy." What going on behind the scene is a lot of effort and work put in. Nobody really talks about their disagreements with eachother openly. Or how they stressed about making sure they saved just enough money to afford rent. Or similar scenarios. A happy relationship does have its bumps.

3

crazyhadron t1_j88e6ey wrote

Reply to comment by randompersonx in Metformin regulates myoblast differentiation through an AMPK-dependent mechanism (Feb 2023) by basmwklz

>metformin has also been shown to have beneficial effects on multiple otherdisorders such as cancer, anxiety, polycystic ovary syndrome,cardiovascular and Alzheimer diseases

According to the linked paper in this post.

I've never heard about metformin affecting the liver, only the kidneys through lactic acidosis. I don't have diabetes, and have been on metformin for 4+ years now. Had a full medical checkup 5 months ago, with an exhaustive blood test. Everything was more than optimal, no liver issues either.

7

randompersonx t1_j8899t2 wrote

Reply to comment by crazyhadron in Metformin regulates myoblast differentiation through an AMPK-dependent mechanism (Feb 2023) by basmwklz

When you say benefits, do you mean the on-label diabetes treatment, or off label as a diet aid or longevity drug?

I looked into it as a non-diabetic, and the risk of liver damage seemed too high for me to consider it. Sure it makes sense for people who need it, but I’m unconvinced it is always going to enhance longevity… and it certainly isn’t strictly necessary to lose fat.

8

Possible-Kangaroo635 t1_j882ypo wrote

Reply to Large study provides evidence that goal incongruence can harm romantic relationship satisfaction by glum-platimium

I've been hearing a lot lately that the vast majority of divorces occur because the woman leaves her husband. And the most common reason is that she earns more money than her husband.

It's pretty fucked up.

It also meshes into another phenomenon. Successful women who remain single. They're only interested in men more successful than they are, but the men who fit that description are fine with women less successful than they are. So there are far more available successful women than men.

And BTW, bisexual women don't apply the same standard to men and women they date. The men must be more successful to be of interest, the women do not need to be.

1

anttirt t1_j882s0a wrote

Reply to comment by feltcute in To help solve the problem of too much guilt, a recent study found that placebos can reduce feelings of guilt, even when the person taking them knows they’re receiving placebos. by chrisdh79

Probably not. Having other people (the researchers) approve and validate the process is key.

You know that they know that you're trying to feel less guilty, and since they're "on your side" whether through placebo or not, you're receiving tacit approval.

24

Fixing_The_World t1_j881zzj wrote

Reply to comment by Malalang in A new study has explored changes to the gut microbiome in people with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). The study identified that people who were diagnosed with the condition less than four years previously have altered proportions of certain microbiota species. by rjmsci

Yeah viruses are really nasty. Some will yes to protect their host which is really cool. Look up the term virovore. It is really cool and I think the next breakthrough in antivirals.

2

Malalang t1_j880ahd wrote

Reply to comment by Fixing_The_World in A new study has explored changes to the gut microbiome in people with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). The study identified that people who were diagnosed with the condition less than four years previously have altered proportions of certain microbiota species. by rjmsci

Yeah, I know at least 2 people that got their hearts destroyed by a virus.

Aren't there bacteria strains that kill viruses?

2