Recent comments in /f/science

CsimpanZ t1_j8cpifw wrote

I had a very similar case with our rabbit Simba. He was so young and the circumstances around his death were probably avoidable. It gave me a much more intense and painful sense of loss than when I lost elderly human relatives.

I hope you’re able to find peace with this, I find it helps to remember them and honour them with how you live your life and care for other animals.

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cool_weed_dad t1_j8cphtr wrote

My dad has a friend who got early onset Alzheimer’s in his early 50’s. My dad used to take him skiing but he eventually got so bad he couldn’t even figure out how to put his helmet on. After losing him a couple times because he got confused he had to stop taking him.

My dad is in his early 70’s and looking at the two of them you’d think they were the same age. Losing cognitive function like that ages you extremely fast.

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SaltZookeepergame691 t1_j8colfg wrote

Aye, Figure 3 showing the efficacy vs remdesivir is basically all we need to see. Huge difference in observed 'potency', even accounting for their presentation of different units... and this against a drug that is far from optimal anyway.

>Because if you assumed that they were pure compounds 5 ug/mL is probably somewhere in the 10 uM range, which is not what you’d hope for from a potential hit.

Indeed. 99% of SciRep papers reporting successful anti-SARS-CoV-2 activity fall over completely at the first glance of the concentrations used/required.

Guarantee no one is gonna want to/be physiologically able to consume enough of these extracts to achieve 10 uM lung tissue concentrations, even if these extracts are absorbable, survive the GI tract, accumulate in lung, and don't kill or maim you first.

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MrGingerlicious t1_j8coklq wrote

Exactly. In my case, my Cat had either a) A Genetic Bone Disease or b) Bone Cancer.

Even if he was Human, that doesn't give you many treatment options. Being a Cat, it isn't even an option.

If he were an 80+ yr/old relative, you could just say "Hey, the chemo isn't worth the suffering, but you've had a good run and we'll make the rest of your time is comfortable". But as an almost 12 yr/old Cat, it was "We have to put him to sleep now, he won't eat and isn't doing well" on the spot, no real time to think or get second opinions or treatment options.

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HippyHitman t1_j8cne6n wrote

I think another huge difference is that most human death isn’t preventable. It either happens suddenly, or medical care just can’t fix it.

With pets it’s rare to actually explore all the treatment options, because who can afford to spend thousands of dollars on a coin flip treatment that will at best add a couple years? And would that even be in the pet’s best interest?

With humans those generally aren’t things you have to worry about. With your pet, you have to make those decisions for them.

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Bkeeneme t1_j8cmga1 wrote

I tried to build an app around this idea- it would pay a few seconds of a playlist and keep doing so till you heard one you liked. Unfortunately, no programmer I enlisted to do the task could figure out how to make it work within the confines of what Apple Music or Spotify would allow but man I still hope one day someone will figure this very simple problem out.

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Sminada t1_j8clorn wrote

While this is true, there was still a considerable number of other people who were affected. Most countries in Africa have lower obesity rates and life expectancy than, for example, the US. But the access to good medical care is lower. You can't just take the official numbers at face value. Take Tanzania: President Magufuli has done everything in his power to cover up outbreaks or even the mere existence of the virus. There was no vaccination program, no testing, no safety regulation, and the hospitals were not prepared. This led to a lot of people just dying on the streets. Cases that could easily have been prevented.

"Fun" fact: President Magufuli himself died of a mysterious lung disease. The government denied it was covid...

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Simmons54321 t1_j8cl2ro wrote

These studies blow balls. This sub has been dominated by mundane finds, considering we bloody well live this thing called life.

Music either hits you initially, or takes time to grow on you. It finds you when you’re ready for it. This business of quantifying everything has its limits, and has become tiresome.

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