Recent comments in /f/science

Michaelcycle13 t1_j8svy72 wrote

Reply to comment by YourFriendNoo in Scientists find people with Long Covid have 2 major cytokines of the immune system (IL-8, IFN-γ) reduced by 100% by sagdiyev1

Get a micronutrient test done, check your Zinc and Vitamin C levels. They're likely depleted. Zinc and Vitamin C have fundamental roles in nourishing the gland which creates Cytokine molecules (Thymus Gland). Vitamin D also plays a crucial role. If we are insufficient in the nutrition that's responsible for Cytokine function, I would imagine that by bringing the nutrients to healthier levels would lead to higher cytokine levels. Issue is is that prolonged malnutrition of the Thymus gland actually leads it to have atrophy, which will mean lessened fundamental function. The sooner we replenish our Thymus, the better.

Virus's love to deplete Vitamin C and Zinc, because Vitamin C and Zinc are so readily necessary for Cytokine (immune fighting T Cells) to deploy and fight the virus. So not only will the virus deplete these key nutrients, but the key nutrients will be depleted leading to insufficient immune fighting function. Its a loop if you will.

For example, I have had a micronutrient panel done, I have resoundingly low levels of Zinc and Vitamin C. And now looking back realizing that during my last infection, I didn't even have a fever. It was extremely mild. Which is and could be in indication of a under functioning deployment of Killer T Cells to be sent out to fight the virus. As a indication that your T cells are busy fighting the virus is to have a fever, it is the body's natural process for killing viral material. Which makes me think, "Just think how many of us had "mild" or "asymptomatic" infections (no fever). Maybe even from the jab itself. Could our immune system of just been depleted? Hence leading to viral persistence within us still?"

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hat_eater t1_j8sv3hw wrote

Reply to A broad-spectrum synthetic antibiotic that does not evoke bacterial resistance by geoxol

Summary

Background

Antimicrobial resistance (AMR) poses a critical threat to public health and disproportionately affects the health and well-being of persons in low-income and middle-income countries. Our aim was to identify synthetic antimicrobials termed conjugated oligoelectrolytes (COEs) that effectively treated AMR infections and whose structures could be readily modified to address current and anticipated patient needs.

Methods

Fifteen chemical variants were synthesized that contain specific alterations to the COE modular structure, and each variant was evaluated for broad-spectrum antibacterial activity and for in vitro cytotoxicity in cultured mammalian cells. Antibiotic efficacy was analyzed in murine models of sepsis; in vivo toxicity was evaluated via a blinded study of mouse clinical signs as an outcome of drug treatment.

Findings

We identified a compound, COE2-2hexyl, that displayed broad-spectrum antibacterial activity. This compound cured mice infected with clinical bacterial isolates derived from patients with refractory bacteremia and did not evoke bacterial resistance. COE2-2hexyl has specific effects on multiple membrane-associated functions (e.g., septation, motility, ATP synthesis, respiration, membrane permeability to small molecules) that may act together to negate bacterial cell viability and the evolution of drug-resistance. Disruption of these bacterial properties may occur through alteration of critical protein–protein or protein-lipid membrane interfaces—a mechanism of action distinct from many membrane disrupting antimicrobials or detergents that destabilize membranes to induce bacterial cell lysis.

Interpretation

The ease of molecular design, synthesis and modular nature of COEs offer many advantages over conventional antimicrobials, making synthesis simple, scalable and affordable. These COE features enable the construction of a spectrum of compounds with the potential for development as a new versatile therapy for an imminent global health crisis.

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IridescentGarbageCat t1_j8sqwrm wrote

Reply to comment by MelancholyMeltingpot in Cannabidiol modulates excitatory-inhibitory ratio to counter hippocampal hyperactivity by Defiant_Race_7544

I believe the initial effect is briefly raising your blood pressure and heart rate, followed by those things lowering. The initial spike can cause anxiety, since the heart rate comes first and once the mental aspect of anxiety is triggered it's hard to soothe. People who have anxiety may feel their body reacting and think, oh no I'm anxious. This is partly why exercise helps anxiety long term past the release of energy, since it lowers resting heart rate.

I've also heard that the anxiety effects can come from worrying about getting caught, so I'm curious if you're experiencing this is an accepting and legal environment.

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QuestionableAI t1_j8spqfr wrote

Reply to A great sense of purpose may help adolescents to be happier and more satisfied with life. by lenova_kobuda

I know this is just a stupid one-off and I'm old ... but, when I was a child I listened to the speeches made by a young senator from Massachusetts who the ran and won the presidency. As he would speak, I would write down every word. I became fascinated with him, his message, and how he got to where he was. My folks told me he went to college, got his law degree and so forth. That set me on the path. No. I never ran for office but got a phd and had a great life teaching and doing research because I chose to and was able to work myself thru college. But, it was the ideas of law, politics, and government that fascinated me and gave me my livelihood.

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