I'm working on the idea of "housing cooperatives" similar to how Habitat for Humanity works. You put in some sweat equity and end up with a house a lot cheaper than developer prices.

I've done property development for myself my whole life. That's either upgrading an existing home, or building from bare land. And I did it as a side gig while having a regular day job.

The stuff I can handle I did myself, and hired contractors for the big heavy jobs. It is not that complicated, you just have to show people how and have a plan. You do need some starter capital, at least enough to buy some bare land and put the utilities in, or for a down payment on a "fixer-upper" that you can then upgrade.

It's a strange question to lead the article because high levels of serotonin can cause hallucinations and will cause serotonin syndrome. We don't all have serotonin syndrome because the homeostatis of neutrotransmitters is tightly controlled.

Not to be a pooper of parades but the same thing happened to me, I thought i was better, I got a cold that other people got over in a few days. I was hacking up phlegm for over a month, had a hard time breathing for a few days. Also vaccinated. Best of luck staying healthy.

Believe it or not - straight to jail.

Tell that to wealthy multinational investors looking for property. Until supply of housing is increased were stuck with this I feel

That’s good! I believe that it can be misleading to assume that because your thymus appears healthy on a CT scan that your immune system is functioning to par. Be sure you have the vitamin C, D, and Zinc in optimal ranges. There are other residual effects from the virus as well such as gut dysbiosis which is cause a number of continuous downstream effects if gone untreated. I did not mean to say any thymus dysfunction is the explanation for long Covid in it’s entirety. There is malabsorption of vitamins, nutrients, and amino acids; gut permeability, organ inflammation, dysfunction in Short Fatty Chain Acid synthesis, neurotransmitter synthesis, and a likely overgrowth of bad bacteria and yeast.

I hate when the title is obvious click-bait like this.

Yeah, that was pretty good, thank you.

exact same for me and i am finally getting my brain back to normalish. i was vaccinated too.

There exist certain antibiotics that do not allow for resistance in the first place—an easy example is alcohol. This concept is not only theoretically possible, it's something that already exists.

Now, if you'll permit me to say so...there's no need to be so cynical. Not only is that sort of cynicism going to bring you down, but it's the entire reason everyone's so anxious and depressed these days...social media amplifies negativity. If you don't have actual criticisms of the science described in this paper, it's probably best to keep the unfounded negativity to yourself.

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I was first diagnosed in late August 2022.

Higher interest rates have knocked the stepladder out from under rising prices. People can't afford the higher priced houses because the monthly payments are too high.

Interesting, might also explain why SSRIs are known to blunt psychedelic effects.

This also seems to suggest 2A agonism is at least partially related to neuroplastic effects, which would definitely hamper efforts in creating "trip free" derivatives.

I wonder how this relates to 5-HT2A-mGlu2 heterodimers.

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Well, I’m in the USA so I guess I’m out.

I read this article on my smartphone.

I think quoting the Moncrieff paper is a mistake here - that's an article with an agenda. Depression is not caused by lowered serotonin activity, sure, but compounds that primarily modulate the serotonin system do relieve it. It's up to the field to unravel the mechanisms behind this. Do these intracellular 5ht2as kick off pathways that surface receptors don't? How do different serotonin agonists affect these receptors? This is exactly the kind of research the field needs to answer these questions.

Sugars (looking at you fructose) results in the production of damaged VLDLs which elicit an inflammatory response on blood vessel walls, causing them to leak. Cholesterol's job is to plug leaks.

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It's cheaper bc corn is subsidized in the US as well.

Receptor binding and conformational dynamics is highly complex. Just because two chemicals bind at the same site, doesn't mean they elicit similar outcomes. Rarely do chemicals bind to only one site either.

The serotonin hypothesis of depression will just not die. 2022 - "The main areas of serotonin research provide no consistent evidence of there being an association between serotonin and depression, and no support for the hypothesis that depression is caused by lowered serotonin activity or concentrations."

https://www.nature.com/articles/s41380-022-01661-0.

How long did you have it?

I think it's a seasonal response telling you to fatten yourself before winter comes (or dry season if you're in the tropics). Most fruits mature around late summer/early autumn (or close to the end of the wet season in the tropics). So that's when you're going to be hit with a fructose rush, which tells your brain, "hey, tough times ahead, better go out and find food while you can!".

Yes, but not free will does not equal free will right?

Nor does theoretical mathematics provide any evidence to suggest that free will exists. Or am I wrong?

Edit - Actually no, 1.9999... only equals 2 if we assume that infinity exists. If we have a limited number of "nines" the equation does not equal 2.

So to make the claim that 1.999 recurring equals 2 you would first have to prove the existence of real infinity, not just a theoretical/mathematical infinity.