Recent comments in /f/science

peer-reviewed-myopia t1_j8wac9x wrote

I think it's a mistake to say compounds that primarily modulate the serotonin system relieve depression.

Considering the delayed 'time of effect' of the therapeutic actions of compounds targeting the serotonin system, it's clear the adaptive structural / functional changes are not specific to serotonergic signaling — be it at the synaptic, or intracellular level.

For example, underlying these changes in plasticity are interactions with the BDNF system, as pretty much all effective antidepressant therapies lead to increases in levels of BDNF mRNA.

There are plenty of other systems at play, and they interact via a variety of feedback mechanisms to regulate the circuits involved in affective behaviors.

3

onyerbikedude t1_j8w9log wrote

There could be a correlation between bipolar and alzheimers although my gut feel is that am sceptical of this. I have bipolar, had it for 26 years (developed it at 25 yrs old). I have always had a somewhat poor short term memory but I considered this was because I am usually thinking about several 'higher' topics rather than concentrating on the minutae of day to day functions. There has been demonstrated an association between abdentmindedness and high intelligence. And bipolar people are often highly intelligent. ..

1

ActualMis t1_j8w71of wrote

Over the years I've had several dogs, and they all had this thing where, if they had to pee/poop inside for some reason (I'm late coming home, they had the runs or something) they always went in the bathroom. My one dog would even hop into the bathtub and go there.

31

Pigrescuer t1_j8w5ij7 wrote

I have small dogs that can't reach door handles, luckily, but we have a friend with a border collie who has let herself into our house in the past (our house open onto a green and we often leave the front door unlocked during the day).

She once let herself in, released my dog from the living room, and I glanced out my office window during a zoom meeting to spot them both running laps around my (human) friend on the green outside.

103
−2

Erebus172 t1_j8w4vlh wrote

The whole point of this article is to say that the anticonvulsant drug lamotrigine (Lamictal) may be a "miracle cure" for autism. There are several problems with this. For one, epilepsy is the most common comorbidity with autism occurring in around 33% of the autistic population. Many of those afflicted with both are already on Lamictal and see no change in their autistic symptoms. Second, as stated in the article, several studies have been done with Lamictal in the past for children with autism and other neurological conditions and showed no effects other than the original (anticonvulsant).

>The drug was ineffective in a small 2001 trial of 28 autistic children, but it may help people with certain genetic conditions.

IMO the manufacturer is just trying to find more people to sell their drug to.

97