Recent comments in /f/science

hallgod33 t1_j8x3mjs wrote

Reply to comment by FUNNY_NAME_ALL_CAPS in Psychedelics activate the same receptors as serotonin, so why aren't we always tripping? Psychedelics may cause neuronal plasticity and relieve depression by activating intracellular serotonin receptors that serotonin itself cannot, suggests a new study. by rjmsci

True that, a lot of Shulgin's work will never be peer reviewed so its hard to elucidate which compounds are providing the effects through human models. And the human models are self-reported and all that. But there are non-psychoactive preparations of a bunch of classical psychedelics that provide anti-depressant effects. What makes it non-psychoactive and effective is hard to pinpoint but Shulgin had a lot of raw data available for anyone interested to explore.

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FUNNY_NAME_ALL_CAPS t1_j8x2ez3 wrote

Reply to comment by hallgod33 in Psychedelics activate the same receptors as serotonin, so why aren't we always tripping? Psychedelics may cause neuronal plasticity and relieve depression by activating intracellular serotonin receptors that serotonin itself cannot, suggests a new study. by rjmsci

As far as I'm aware 2-bromo-LSD doesn't have antidepressant efficacy. There are now a few substances that labs believe are non-psychoactive and retain antidepressant efficacy, but they base this off mouse head twitch response and they have yet to be validated in humans.

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FraseraSpeciosa t1_j8wzort wrote

Reply to comment by RabidBeaverLake in Religious Hermit Found Buried in The Fetal Position. The woman buried was living with septic arthritis and also advanced venereal syphilis. This would have meant she lived with severe, visible symptoms of infection affecting her entire body, and later on, neurological and mental health decline by Wagamaga

It’s amazing, after all these years, people still fall for the logical fallacies she did. It’s sad more than anything. These kinds of people are trapping themselves.

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dumnezero t1_j8wvq3v wrote

Reply to "Findings indicate a negative log-linear relationship between per-capita GDP and adolescent life satisfaction." by PaulHasselbaink

> PISA test scores and levels of student competition are consistently negative, and levels of student co-operation enter positively. It is interesting to note how, at the macro level, we find that average academic performance is negatively related to students’ SWB, while earlier studies focusing on the link between individual performance and individual life satisfaction usually report a positive link (see Bücker et al., 2018, for a meta study). Note that this is not a contradiction. At the individual level, a student can improve her SWB by performing better in school than her peers. However, at the macro level, overall academic performance and competition within schools increase learning intensity and school-related stress for each student, reducing SWB for the group as a whole. We therefore argue that the intensity of education—which increases with the level of economic development—is very likely to be the mechanism behind our findings.

All work and no play...?

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hallgod33 t1_j8wtwpw wrote

Reply to comment by FUNNY_NAME_ALL_CAPS in Psychedelics activate the same receptors as serotonin, so why aren't we always tripping? Psychedelics may cause neuronal plasticity and relieve depression by activating intracellular serotonin receptors that serotonin itself cannot, suggests a new study. by rjmsci

Trip-free derivatives already exist, like bromo-LSD is used for cluster migraines. Shulgin invented a boatload of non-psychedelic analogues to the classical psychedelics.

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danielravennest t1_j8wp7xz wrote

Reply to comment by ShelbySmith27 in New UC San Diego model predicts housing prices to fall as much as 18% this year by Sofie-Forsberggg

> There isn't enough supply of land

I live on the outskirts of the Atlanta metro area. Beyond where I live, there nothing but undeveloped forest. Developers have been gradually buying up and building, which is how Atlanta has grown. My little town has a "seed and feed" store and a Tractor Supply store. Both of those cater to farmers and large land lots, not 1/4 acre suburban. They would not be here if there weren't the kind of owners they cater to.

> Your plan only works if the person has enough capital

I'm an engineer, so I had enough income to do it. But not everyone does, which is why I mentioned a cooperative approach. People pitch in a little bit each, plus their labor, and fix up or build one house at a time to start with. One of them takes out their share and buys it conventionally. The loan proceeds then return the capital to the group so they can work on the next.

If you get one member like myself who has the spare capital, the other members don't have to contribute anything but labor.

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nerd4code t1_j8wnydh wrote

Reply to comment by Critical_Cress_6106 in Compared to wolf pups and kittens, dog puppies tend to spontaneously match actions demonstrated by a human — even in the absence of food rewards by marketrent

Ours tried peeing on our cats’ litter boxes for a bit, but TBF he’d pee aggressively (with eyes locked to mine) so Idunno if it was imitative or retributive, or if he just decided all the pee smells belong together.

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SanaFraley t1_j8wnsv5 wrote

Reply to comment by Michaelcycle13 in Scientists find people with Long Covid have 2 major cytokines of the immune system (IL-8, IFN-γ) reduced by 100% by sagdiyev1

I don't fully understand your question. If you mean my acute infection, it was bad, 91% spo2 bilateral delta pneumonia. If you mean my long covid symptoms....2 years of pure hell....burning hands/feet, blurred vision, sob, chest pains, brain fog, dysmotility. To name a few.

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