It's complicated. It could push some species to extinction, which would generally be considered bad.

I have put off reading that book for too long

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> I can drink a cup of hot urine

Prove it!

my most recent triglyceride level was 59 and LDL 62, so i'm hoping low is good.

LDL alone has always been a bad marker for cardiovascular health. For one, 75% of heart attack victims have normal LDL range. Second, there are 4 types of LDL that are raised from different sources. Type 1 and type 2 LDL are harmless and actually beneficial but type 3 and type 4 are what is harmful. Type 1 and type 2 are raised via animal fats, type 3 and 4 are raised via processed foods, sugars, and simple starchy carbohydrates. It all relates the globule sizes as the larger type 1 and 2 are too large to get stuck on lesions in blood vessels but the smaller sized 3 and 4 are what is a risk for getting stuck in the artery walls. So just general LDL levels isn’t very informative, you need the more advanced testing that breaks it into subtypes.

In addition, the 5 meta studies performed over the last 20 years have never been able to draw a meaningful association between LDL and heart disease or early mortality. Meanwhile the these studies have always shown a direct strong correlation between blood triglyceride levels and early mortality. So when you get a blood panel, more important to look at the triglyceride levels than LDL. Hope this helps.

I have to wonder if kids with poor executive function and inattentiveness/hyperactivity are more likely to be abused (hence higher ACEs), resulting in elevated risk for BPD.

I also have to wonder if the poor executive function and inattentiveness/hyperactivity are temporally preceded by increased ACEs—in other words, I wonder if ACEs might cause some of the ADHD-like features.

It’s also possible that neither is true (in which case both are probably just risk factors), or that both are true (in which case they all interrelate).

I’m not a researcher in developmental psychology, so I…really don’t know enough to answer my own queries.

I'm calling it now. We're gonna get jackasses demanding "non-GMO wood" for their homes.

> How common is it that trauma survivors are diagnosed with anxiety disorders?

Very

... so low LDL is still good?

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Introduction: The discovery of immune checkpoints and the development of their specific inhibitors was acclaimed as a major breakthrough in cancer therapy. However, only a limited patient cohort shows sufficient response to therapy. Hence, there is a need for identifying new checkpoints and predictive biomarkers with the objective of overcoming immune escape and resistance to treatment. Having been associated with both, treatment response and failure, LDL seems to be a double-edged sword in anti-PD1 immunotherapy. Being embedded into complex metabolic conditions, the impact of LDL on distinct immune cells has not been sufficiently addressed. Revealing the effects of LDL on T cell performance in tumor immunity may enable individual treatment adjustments in order to enhance the response to routinely administered immunotherapies in different patient populations. The object of this work was to investigate the effect of LDL on T cell activation and tumor immunity in-vitro.

Methods: Experiments were performed with different LDL dosages (LDLlow = 50 μg/ml and LDLhigh = 200 μg/ml) referring to medium control. T cell phenotype, cytokines and metabolism were analyzed. The functional relevance of our findings was studied in a HCT116 spheroid model in the context of anti-PD-1 blockade.

Results: The key points of our findings showed that LDLhigh skewed the CD4+ T cell subset into a central memory-like phenotype, enhanced the expression of the co-stimulatory marker CD154 (CD40L) and significantly reduced secretion of IL-10. The exhaustion markers PD-1 and LAG-3 were downregulated on both T cell subsets and phenotypical changes were associated with a balanced T cell metabolism, in particular with a significant decrease of reactive oxygen species (ROS). T cell transfer into a HCT116 spheroid model resulted in a significant reduction of the spheroid viability in presence of an anti-PD-1 antibody combined with LDLhigh.

Discussion: Further research needs to be conducted to fully understand the impact of LDL on T cells in tumor immunity and moreover, to also unravel LDL effects on other lymphocytes and myeloid cells for improving anti-PD-1 immunotherapy. The reason for improved response might be a resilient, less exhausted phenotype with balanced ROS levels.

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They heard wind of the kudzu advance and are trying to flee

Do you have a problem with superwood? It's enhanced with the power of ancient forests.

I expect royalties if you use this, marketers.

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i'm a teacher. We do 5 min of mindfulness breathing at the beginning of every class.

I have the happiest, most joyful students.

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That’s interesting - where do you live?

It really doesn't though. Out here in the US pacific NW, timberline lodge on Mt hood is an example. You get to an elevation where it's simply too cold for trees to grow any further up. Obviously close to the lodge the flora are somewhat maintained, but the altitude and temp have kept it tree free since before white guys showed up. Succession simply can't happen, at least currently.

It is. There’s plenty of evidence of it in the Americas.

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My dad has it, he was not impressed when the receptionist at the doctortold him that he'll need to go see a dentist instead.

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