>This doesn’t have much use for physical applications. It’s kind of particle physicists doing particle physicist things.

Would you say it's similar to the math community calculating more digits of pi?

Emphasis added.

“The intracellular VC concentration is strictly regulated in order to maintain levels of 80–100 μM in the plasma [2, 3]. However, intravenous injection bypasses this strict regulation, allowing specific VC concentrations to be maintained within a specified period, thereby providing a pharmacological basis for its therapeutic application [4]. Several pioneering studies have demonstrated the efficacy of pharmacological VC in improving the survival of patients with advanced cancers [5, 6]. In contrast, two randomized double-blind controlled trials failed to demonstrate any benefit of VC against advanced malignant disease [7, 8]. Therefore, the route of administration is important for high-dose VC to have a therapeutic effect, and only intravenous administration results in sufficiently high plasma and urine concentrations to allow potential antitumor activity [9].”

Hold up. Wait until we finish arguing before we attempt either one.

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The authors are using the term pharmacological to refer to plasma concentrations that are only achievable by IV administration.

Per the authors, the body regulates Vitamin C to 80-100uM so you can't just consume more of it. IV administration however gets around the natural intestinal absorption limits.

So unless you plan to shoot up your supplements, this doesn't seem applicable to typical person just yet. Though I must say I'm imagining a funny skit where we see what appears to be a drug den of people shooting up and it's a bunch of natural herbalist types cooking up and injecting vitamin c from a pile of oranges.

it seems to me theyre just trying to avoid saying "megadose"

While I agree with the sentiment, it is mostly not poor people who are doing this. Sure, often they are used as pawns to start the clearing, but some big miners and landowners, as well as companies, are the ones profiting.

Fair comment.

The headline is confusing first we say fat is protective then we say it causes dementia and stroke so either it is beneficial or dangerous this headline is a true mystery indeed.

While Brazil bears responsibility, let's not forget that what is mined or produced there is for global supply chains. So fostering due diligence in supply chains, regulations, etc should be done by the recipient countries as well.

To be clear, you're not missing anything, there is no difference between "pharmacological vitamin C" and vitamin C. They are both ascorbic acid.

The motivations for using this obfuscating term are unsupported in the text and make no sense.

Does the more precise measurement resolve or make more puzzling the g-2 (dipole anomaly) announced by Fermilab a few months ago?

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This is something my friends and family struggle to understand about me. I don’t feel better and accomplished after I face something that makes me anxious. The feeling lingers and it doesn’t feel good. I really do feel better mentally when I avoid situations that cause anxiety.

Emphasis added.

“The intracellular VC concentration is strictly regulated in order to maintain levels of 80–100 μM in the plasma [2, 3]. However, intravenous injection bypasses this strict regulation, allowing specific VC concentrations to be maintained within a specified period, thereby providing a pharmacological basis for its therapeutic application [4]. Several pioneering studies have demonstrated the efficacy of pharmacological VC in improving the survival of patients with advanced cancers [5, 6]. In contrast, two randomized double-blind controlled trials failed to demonstrate any benefit of VC against advanced malignant disease [7, 8]. Therefore, the route of administration is important for high-dose VC to have a therapeutic effect, and only intravenous administration results in sufficiently high plasma and urine concentrations to allow potential antitumor activity [9].”

Norman Cousins was saying as much decades ago.

It might be a difference. Or not. I believe the term was used because the study was done on supplement vit c.

> Is this a sarcastic question?

Indeed. The way it's worded almost sounds like marketing.

I havnt reddit. Biochemistry grad. The distinction I think pharmacological is making... is that they isolated variables by simply using ascorbic acid.

Probably not as thorough as rapamycin.

Unless the authors believe there's a difference between pharmacological and natural vitamin C they should just say 'vitamin C'. Otherwise it makes it sound like it's work that's been done by or for a supplement company.

>Pharmacological vitamin C (VC) is a potential natural compound for cancer treatment.

Pretty sure they are the same thing (abscorbic acid). Chemistry's chemistry, whether it be from a fruit or from someone's lab

Mindfulness is not behavioral modification— it’s about learning to recognize and sit with the reality of the present and what your senses reveal about that state. Behavioral modification is about training yourself into good habits through small actions which eventually lead to bigger ones. Eventually mindfulness can lead to behavioral change once the individual becomes aware of actions that do not serve them well, but the onus for change comes from a completely different place

I doubt it's more efficient than planting a seed and taking care of the small plant while it's growing