Recent comments in /f/science

contaygious t1_j98kmje wrote

Reply to Females' propensity to deposit more fat in places like their hips, buttocks and the backs of their arms, so-called subcutaneous fat, is protective against brain inflammation, which can result in problems like dementia and stroke, at least until menopause, scientists report. by QualityWork_

So... Their use of commas suggests the fat is causing the the Dementia.... Right? How can it be protective and cause it.

They shouldn't use a comma after the word fat then. Super confusing Grammer bro

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Darkhorseman81 t1_j98ivtb wrote

Reply to comment by [deleted] in Pharmacological vitamin C inhibits mTOR signaling and tumor growth by degrading Rictor and inducing HMOX1 expression (Feb 2023) by basmwklz

Mega dose is stupid. The body uses what it needs in the moment and excretes the rest.

Slow release Vitamin C, 24 hour slow release, is what you need.

Ancient humans had genes to produce their own constant low supply Vitamin C. These genes were lost or silenced.

This has lead to loss of epigenetic quality control, particularly in blood. As Vitamin C regulates a quality control gene called TET2, which is related to DNMT DNA methyltransferases.

Means we can mutate more and evolve quicker, but makes us more predisposed to cancer, oxidative damage, and dysfunction.

When we were monkeys eating lots of fruit, almost constantly, I guess our body thought it was a good trade-off.

Now with drought flood drought flood levels of Vitamin C in the modern diet, it's lead to epigenetic chaos.

Deficiency in Queuine, unpredictable Vitamin C and Folate levels leads to aberrant oxidation states in Tetrahydrobiopterin, for starters.

Loss of Mitohormensis, as one of a million things this leads to.

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Darkhorseman81 t1_j98ihjn wrote

Reply to Pharmacological vitamin C inhibits mTOR signaling and tumor growth by degrading Rictor and inducing HMOX1 expression (Feb 2023) by basmwklz

Vitamin C regulates TET2, a gene that regulates epigenetic quality control in the blood.

It is so efficient, if you get a loss of function mutation of TET2, Vitamin C can replace its function, weirdly enough.

I'm on my phone so it's a hassle to link studies, but type Leukemia tet Vitamin C into a search engine. Some pop up pretty easily.

Vitamin C alone can treat some forms of Leukemia.

Some, not all. Don't expect it to be a miracle cure or anything.

It's weird, but ancient humans had the ability to produce Vitamin C from Glucose. Over time, through mutations and silenced genes, we became Vitamin C auxotrophs, requiring it from the diet.

The way we evolved our bodies do not stock pile it like oil and fat soluble vitamins, because we used to make what we needed on demand; there was no need.

Now, we use what we need in the moment and excrete the rest.

The loss of this Vitamin C producing capability lead to epigenetic instability. Means we can mutate and evolve faster, but also means we are more prone to cancer and dysfunction.

I've added a 24 hour slow release Vitamin C in its native form to a muscle wastage and anti aging protein powder I'm working on.

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AimlessZealot t1_j989n6g wrote

Reply to comment by [deleted] in Reflexive fear responses tend to linger in people with anxiety disorders, study suggests by chrisdh79

No, that's exactly what you're saying. They stated it was vague because "it had to be," implying repercussions if they were too identifiable. The nature and purpose of whisper networks (which operate exclusively through gossip) is to allow important information and warnings to spread without such dangers.

By insisting that only those who can make clear accusations ever speak of issues, you are also stating anyone who faces jeopardy should either accept additional risks or not bother trying to pass any information. The worst this person's statement could lead to is others watching critically for a reason why or investigating further. That's a good thing, I think.

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xenonrealitycolor t1_j989gq2 wrote

Reply to Researchers discovered a brain circuit that inhibits motivated behaviors, emphasizing a new perspective for studying and treating addiction by giuliomagnifico

So it seems activating this prevents motivation of risky behaviors, but only to a certain extent. It would be a good idea to test how much deactivation of this circuit would ultimately help people with schizophrenia (similar) major depressive disorder, PTSD, ADHD, and other disorders that significantly prevent people from being able to do anything because of significant motivation and other brain issues.

I would love to see the results on myself after a year of deactivation of this to see what I could get done myself considering my major depression, anxiety, and more.

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