Recent comments in /f/science

vomex45 t1_j9sm63e wrote

Reply to comment by Please_Log_In in Researchers have found that a Parkinson’s-linked mutation in a gene called Endophilin A1 blocks the process by which the body and the brain recycle cell waste. Without the process, autophagy, toxic debris builds up and neurons die. This discovery could change the focus of Parkinson's treatments. by QldBrainInst

Parkinson's is not the sort of thing that can be fixed with lifestyle changes. "Big Pharma" making Carbidopa/Levodopa is the sole reason my dad has been even remotely functional for the last 15 years.

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mattrussell2319 t1_j9slcco wrote

Reply to comment by Not_as_witty_as_u in Researchers have found that a Parkinson’s-linked mutation in a gene called Endophilin A1 blocks the process by which the body and the brain recycle cell waste. Without the process, autophagy, toxic debris builds up and neurons die. This discovery could change the focus of Parkinson's treatments. by QldBrainInst

These aren’t plaques in the figure, it’s an experiment to show autophagy induction. The structure in panel G’’ in the figure that also appears as a red dot in the colour images, is associated with autophagy, a process of removing and recycling cell waste. The red shows where one of the autophagy proteins is. Here, an Endophilin A1 mutant is used that doesn’t need a calcium signal to turn it on. So they’ve shown that this ‘on’ state makes autophagic structures form.

Later in the paper they show that a different mutation of Endophilin A1 associated with Parkinson’s is an ‘off’ state mutation, and inhibits autophagy. So you’d see fewer of those autophagic structures, and since autophagy helps clear the stuff that causes plaques, this PD associated mutant could lead to plaque formation.

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dec0y t1_j9sl46b wrote

Reply to comment by PerformanceNow in Brain changes in fighter pilots may cast light on astronauts during space travel: Study finds that pilots show ley changes in brain connectivity and they may function as suitable test subjects to learn more about space travel. by DreamingForYouAlways

If anything, I think fighter pilots have a more strenuous experience than astronauts. They have to deal with intense fluctuations between high and low Gs, and I imagine that cannot be very healthy for the brain.

Astronauts do experience relatively high Gs during launch, but nowhere near what fighter pilots experience during high maneuverability exercises - and after a brief launch, the rest of their mission is entirely in 0G.

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grrrrrlar t1_j9skr5b wrote

Reply to comment by Skele_again in Study Finds Topical Hemp May Treat Anal Fissures and "Significantly Improves" Symptoms by BoundariesAreFun

My wife has a similar story. No kids but got abscesses and fistulas/fissures from untreated Crohns, she lost the same amount of weight as you. It was painful to watch. Do you have anything that has helped? It is likely you have ptsd, it’s common in those with chronic illnesses/autoimmune. I’m hoping you’re feeling better <3. You got this!

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Please_Log_In t1_j9skj7l wrote

Reply to comment by pace_gen in Researchers have found that a Parkinson’s-linked mutation in a gene called Endophilin A1 blocks the process by which the body and the brain recycle cell waste. Without the process, autophagy, toxic debris builds up and neurons die. This discovery could change the focus of Parkinson's treatments. by QldBrainInst

Big Pharma always recommends medicalization over lifestyle changes: their priority is profits

EDIT: i'm not denying the need for medication, in many cases it's the best way to treat symptoms.

I'm just cynical about medicalization in general.

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Honigwesen t1_j9ske1v wrote

Reply to comment by Roughneck16 in Researchers have found that a Parkinson’s-linked mutation in a gene called Endophilin A1 blocks the process by which the body and the brain recycle cell waste. Without the process, autophagy, toxic debris builds up and neurons die. This discovery could change the focus of Parkinson's treatments. by QldBrainInst

There are none.

Levodopa and the rest are just treating the symptoms. There's nothing to stop progress or even reverse it.

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OneWorldMouse t1_j9sitkg wrote

Reply to comment by hippydog2 in Researchers have found that a Parkinson’s-linked mutation in a gene called Endophilin A1 blocks the process by which the body and the brain recycle cell waste. Without the process, autophagy, toxic debris builds up and neurons die. This discovery could change the focus of Parkinson's treatments. by QldBrainInst

Knowing the different ways neurons die and preventing their deaths are giant leaps.

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nearfar47 t1_j9si7z6 wrote

Reply to comment by Not_as_witty_as_u in Researchers have found that a Parkinson’s-linked mutation in a gene called Endophilin A1 blocks the process by which the body and the brain recycle cell waste. Without the process, autophagy, toxic debris builds up and neurons die. This discovery could change the focus of Parkinson's treatments. by QldBrainInst

alpha-synuclein is believes to be part of the mechanism of pathology in PD. Beta-amyloid plaques is associated with Alzheimer's, but so is tau.

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Skele_again t1_j9shirf wrote

Reply to comment by Silmelinwen in Study Finds Topical Hemp May Treat Anal Fissures and "Significantly Improves" Symptoms by BoundariesAreFun

Me too. I got one after my daughter was born which (undiagnosed crohns) turned into an abscess. Child birth and wasting away -lost 100lbs w excruciating stomach pain- from crohns over the course of 6 months don't even remotely compare. It's the only time in my life that death seemed like a good option to stop the pain.

My crohns is still active 16 years later & if I get slightly sore down there from all the bathroom trips I PANIC and worry it's a fissure. Legit wonder if I have ptsd.

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