Recent comments in /f/science

Skele_again t1_j9swtiu wrote

Reply to comment by grrrrrlar in Study Finds Topical Hemp May Treat Anal Fissures and "Significantly Improves" Symptoms by BoundariesAreFun

Oh I'm sorry to hear she also deals w fistulas! I had one and it was awful! I haven't found much that helps, I got into remission once for a couple years after a bowel resection but otherwise I've not had much luck. I did get to try Entyvio when it first came out but didn't have time to let it work before I needed surgery & there's some new drug out that also has great results in studies that I see a lot of people trying. I hope your wife gets a break from it all and gets a good remission. Take care of yourself too! It's hard to be on the sidelines watching!

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Darkhorseman81 t1_j9swtfp wrote

Reply to comment by hippydog2 in Researchers have found that a Parkinson’s-linked mutation in a gene called Endophilin A1 blocks the process by which the body and the brain recycle cell waste. Without the process, autophagy, toxic debris builds up and neurons die. This discovery could change the focus of Parkinson's treatments. by QldBrainInst

Excess S-Nitrosylation blocks it's function in most cases. Mutation would be a rare exception.

We've know this for a while, but they have just shown an extra mechanism by which it happens.

It's why nitrogen pollution from exhaust fumes is linked to parkinsons.

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Darkhorseman81 t1_j9swnof wrote

Reply to Researchers have found that a Parkinson’s-linked mutation in a gene called Endophilin A1 blocks the process by which the body and the brain recycle cell waste. Without the process, autophagy, toxic debris builds up and neurons die. This discovery could change the focus of Parkinson's treatments. by QldBrainInst

Excess S-Nitrosylation blocks it's function in most cases. Mutation would be a rare exception.

It's why Nitrogen pollution is linked to Parkinsons, and why things like Poppers are potentially quite dangerous.

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Wolfm31573r t1_j9srs5k wrote

Reply to comment by Honigwesen in Researchers have found that a Parkinson’s-linked mutation in a gene called Endophilin A1 blocks the process by which the body and the brain recycle cell waste. Without the process, autophagy, toxic debris builds up and neurons die. This discovery could change the focus of Parkinson's treatments. by QldBrainInst

True, L-DOPA only treats the symptoms. If the dopaminergic neurons are already dead at the later stages of the disease, the only way to treat the disease instead of the symptoms would be by dopaminergic neuron transplantation. That stuff its still quite far. At the earlier stages some drugs that can modify the proteostasis in the cells could be usefull, but they are still in development, and even in optimistic scenarios it would take half a decade for them to be available as a treatment.

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PD711 t1_j9srlsb wrote

Reply to Mice Choose Mating Over Food, Even When Hungry by molrose96

Awful headline.

>Researchers have discovered that hungry mice choose interaction with members of the opposite sex over eating and drinking when specific brain receptors sensitive to leptin are stimulated. The study is published in Cell Metabolism.

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juxtoppose t1_j9spj18 wrote

Reply to comment by Crazocrates in A more mystical and insightful psychedelic drug experience may be linked to an enduring reduction in anxiety and depression symptoms, according to new research. The study is the first to characterize subtypes of the subjective psychedelic experience and link them to mental health outcomes. by memorialmonorail

Pretty much my experience, waking up next day with a sore face from smiling/laughing.

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dskippy t1_j9sojuz wrote

Reply to Mice Choose Mating Over Food, Even When Hungry by molrose96

So just got to a party and you've been starving for hours but you were waiting to eat because you know the host makes really great party food. The moment you get in you see the buffet and also an incredibly attractive person approaches you and asks if you want to go upstairs right now and fool around. I don't need a scientist to explain to me how this is going to go.

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HKei t1_j9snrfb wrote

Reply to comment by InTheEndEntropyWins in Research suggests that school-based physical activity intervention, by way of increasing physical exercise classes to daily during school, is successful in reducing childhood obesity. Scientists found that obesity was reversed after 3 years. by Wagamaga

There’s “diet” and there’s “diet”. When talking about short term, people think of restriction based diets that are kind of framed as challenges “do X for Y weeks to get Z”. The “diet” in this “meme” doesn’t refer to that; It simply refers to how you eat habitually. You’re not going to be healthy if you eat a full size cheesecake every day and vegetables pretty much never, even if you exercise a lot.

That said, most peoples diets aren’t quite as bad as that, whereas it’s extremely common for people to never exercise at all or so rarely that it hardly makes a dent.

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Reply to Researchers find 26 Australian species recovered from the brink of extinction by yadavhimanshu961

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Heterophylla t1_j9sn9il wrote

Reply to comment by Sad_lucky_idiot in Companion robots to mitigate loneliness among older adults: "Most participants (68.7%) did not think an Artificial Companion robot would make them feel less lonely and felt somewhat-to-very uncomfortable (69.3%) with the idea of being allowed to believe that an artificial companion is human." by Gueulemer

That’s just a robot dog with extra steps . Plus the robot dog won’t get sick and die .

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vomex45 t1_j9sn9el wrote

Reply to comment by Roughneck16 in Researchers have found that a Parkinson’s-linked mutation in a gene called Endophilin A1 blocks the process by which the body and the brain recycle cell waste. Without the process, autophagy, toxic debris builds up and neurons die. This discovery could change the focus of Parkinson's treatments. by QldBrainInst

There is a number of dugs that can be used in conjunction with each other, namely Levodopa along with others like Carbidopa. Some are prescribed to increase the effectiveness of L-dopa and some are for fighting momentary flare-ups of symptoms, often called "off" times.

There is also a deep brain stimulation operation that can be an option but typically only around 10-15% patients become good candidates for it and less get the operation.

Both these avenues are only strategies to treat symptoms and do not alter the course of the disease. Patients that live long enough will eventually become dependant on the drugs to have any level of functionality at all.

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Beyond-Time t1_j9sn1vm wrote

Reply to comment by Please_Log_In in Researchers have found that a Parkinson’s-linked mutation in a gene called Endophilin A1 blocks the process by which the body and the brain recycle cell waste. Without the process, autophagy, toxic debris builds up and neurons die. This discovery could change the focus of Parkinson's treatments. by QldBrainInst

There is truth for your statement, but the is the wrong thread. There is no lifestyle change that will fix Parkinson's. Perhaps you're a bit account, who knows

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