Recent comments in /f/science

millahhhh t1_ja35o8b wrote

Don't love the title here, the connection between IBS and mental health has been understood for a while, it's even been in the treatment guidelines (Rome) since like 2015. This may be a slight refinement or deeper characterization (as most research is), but the title implies some sort of revelation when it clearly is not

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nomad1128 t1_ja35e27 wrote

Blood vessels are the unifying thing. Most established risk factors for Alzheimer's relate to blood vessel health (hypertension, hyperlipidemia, diabetes, smoking), proxies for bad blood vessels (heart attacks, congestive heart failure, stroke, peripheral artery disease, kidney failure) and aging. Sure enough there is a thing that builds up in blood vessels as we age called medin that seems to be some kind of detritus from stuff that holds vascular cells together. And sure enough there is evidence that blood vessels with medin adjacent to brain lead to amyloid plaques/tangles we have been chasing for decades, but as others have called it, those plaques are the smoke, not the fire.

I suspect when you read about viruses/inflammation being linked to neurodegenerative processes, you're really just talking about leaking medin/other crap into the brain.

I believe an AI study concluded that the strongest risk factor for developing dementia was leaking proteins in the urine. Because proteins aren't supposed to be leaking from anywhere, so if they are leaking in the urine, then they are probably leaking in the brain.

And strongest risk factor for that kind of leaking? Diabetes.

If I were treating stocks like gambling, I would invest it all in any pharmaceutical company that is developing antibody to medin

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pete_68 t1_ja34wfm wrote

Thanks. It's terrifying and we're not 100% sure we're going to be able to do it. We're going to give it a shot, though. And if it works out, it works out and if it doesn't, we'll find some other way to help out.

As part of this process, we've spoken to a lot of foster families and found that they need a lot of support in other ways because there's just so much involved in fostering over taking care of a biological child. There are usually additional doctors appointments, therapists (psychological, occupational, etc), visitation with biological parents, etc.

They need help running errands, making meals, finding clothes, etc. So if we find that fostering's just not meant for us, we'll try to help out in those areas. I love to cook, so cooking up lots of good meals that can be frozen and reheated and in the oven, fresh bread, etc, are things I'd love doing. We could both help with the other things as well.

Fostering is hard. Fortunately, this training gives very realistic expectations because when we first started, my wife, I think, kind of idealized it and this has really kind of opened her eyes as to how hard it is.

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Adam-Ridens t1_ja33p4g wrote

It's new. They are out there, the fact that plastics are getting so small and are able to inhibit cell functions like rna creation is a whole new level of didn't see that coming. It's gunna to be crazy to see how this impacts evolution. The dna Zipper is going to have a lot more hiccups now. This is my hypothesis from my readings and inferences, and I hope nature can prevail.

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SerialStateLineXer t1_ja2xnqq wrote

It's important to note here that twin studies have found obesity to be very strongly heritable with minimal contribution from shared environment.

Since this study used mediation analysis, which can't be used to demonstrate causality, we should be skeptical of causal claims made by the authors.

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