Recent comments in /f/science

Ok-Cut4890 t1_jaq23fg wrote

The anxiety is a secondary symptom of the IBS. I am a naturally very happy person. I have never done the beat myself up internal monologue. The anxiety I get is always very odd and difficult to understand why I suddenly got anxious. My life has always been very easy. I always finish tests first. Writing papers and math were always easy for me. I am always the golden boy at wherever I work. I've been offered free rides to grad school for my work performance. I easily command any conversation I care to.

Anxiety, insomnia, depression. These are things that should be obviously understood as a secondary symptom of something else.

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Meatrition OP t1_japt75k wrote

Abstract

The consumption of isoflavones is gaining popularity worldwide due to their beneficial effects on health. However, isoflavones are considered to be endocrine disruptors and cause deleterious effects on hormone-sensitive organs, especially in males. Therefore, this study aimed to determine if a continuous and prolonged exposure to isoflavones in adult males altered the endocrine axis effect of testicular function. For this purpose, seventy-five adult male rats were administered with low and high mixtures of isoflavones (genistein and daidzein) for 5 months. The determination of steroid hormones (progesterone, androstenedione, dehydroepiandrosterone, testosterone, dihydrotestosterone, 17β-estradiol, and estrone sulphate) was carried out in serum and testicular homogenate samples. Sperm quality parameters and testicular histology were also determined. The results revealed that low and high doses of isoflavones promote a hormonal imbalance in androgen and estrogen production, resulting in a decrease in circulating and testicular androgen levels and an increase in estrogen levels. These results are associated with a reduction in the sperm quality parameters and a reduction in the testicular weight, both in the diameter of the seminiferous tubules and the height of the germinal epithelium. Altogether, these results suggest that a continuous exposure to isoflavones in adult male rats causes a hormonal imbalance in the testes that disrupts the endocrine axis, causing defects in testicular function.

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Meatrition OP t1_japt4t7 wrote

Introduction Genistein is an isoflavone phytoestrogen that induces cell differentiation in tissue culture Constantinou and Huberman (1995). An inhibitor of tyrosine kinase, histidine kinase, and topoisomerase Akiyama et al (1987), Huang et al (1992), Barnes and Petersen (1995), genistein is thought to be an anticancer, antiproliferative, cardioprotective and/or chemopreventive agent. It is possible, however, that the enzyme inhibitory effects may only occur at non-physiological concentrations Belenky et al (2003). At physiological concentrations, genistein activates the nuclear estrogen receptors ER-alpha and ER-beta Kuiper et al (1997), Kuiper et al (1998), Casanova et al (1999) and affects TGF-beta signaling pathways Kim et al (1998). While genistein, or its more soluble glucoside derivative genistin, are taken as a dietary supplement, they have not been thoroughly tested in clinical trials. Common dietary supplements often include other isoflavones, such as daidzein and glycitein or their corresponding glucoside conjugates.

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OpinionSorry1660 t1_japr8af wrote

T for the last few years, never smoked anything but had the occasional ringing in my ears when I was younger. It was like somebody turned a tone generator up to 11 then it would fade out. Now it’s doesn’t fade out anymore and it sounds like cicadas, all the time.

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_OriamRiniDadelos_ t1_japqbmd wrote

An explanation of the Classic Maya collapse is that they deforested so much, over taxes their environment, and got hit by even harsher droughts because if it (Yucatán is not a land of rivers) so that’s why the mountain cities carried on and most the lowland ones suffered.

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NFT_goblin t1_japl09s wrote

There is comorbidity between anxiety, conditions like ADHD and autism, and also muscular/joint pain and joint hypermobility

Just some random google sources to show I'm not making it up:

ADHD and chronic pain: https://edgefoundation.org/adhd-and-chronic-pain/

ADHD, anxiety, and chronic pain are comorbitidies of autism: https://www.nhs.uk/conditions/autism/other-conditions/#:~:text=Problems%20with%20joints%20and%20other,that%20does%20not%20go%20away

Definitely think there is something to this. Anecdotally, I have anxiety, adhd, and also chronic pain that has really wrecked my life over the last few years. I hope some more productive research into this topic will be available soon.

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Carbon140 t1_japisyi wrote

That's very kind. I don't really know if it's over the top to be concerned and it's obviously hard to tell the impact because it's so slow, but I definitely feel like it may be having an impact on me mentally from anxiety etc and also physically in the form of my body burning itself out faster than it needs to. I guess the easy weight control is convenient though. It's definitely frustrating to see something that looks like a problem in the future and have doctors seemingly take the attitude that they will do something about it once I have already fallen apart.

What sort of treatments are there? I know in my father's case his Thyriod overgrow in a nodular fation and when he got cancer the situation became much worse as he also had a wildly out of control heart. I remember him saying that he permanently had that feeling like someone had just popped a paper bag behind his head. If mine is overgrowing it would need surgery to remove part of it or some form of radiation iodine treatment to hamper it's function?

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