Recent comments in /f/science

MrMarquis t1_jb67xnj wrote

Reply to comment by No-Sock7425 in Lung cancer patients with moderate to severe depression at diagnosis are 2 to 3 times more likely to have inflammation levels that predict poor survival rates, a new study found. (n=186) by geoff199

Me. Why be depressed because that's not going to help anything or anyone. I just stay upbeat because it helps keep my family from being all gloomy and doomy. Having a positive outlook can't hurt.

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IamPurgamentum t1_jb6776h wrote

Reply to comment by WyngZero in Humans Started Riding Horses 5,000 Years Ago, New Evidence Suggests by geoxol

The whole timeline seems off to me. Think of how many things that have been invented in the last 100 years and then then 100 before that.

It seems crazy to me that these guys were around supposedly just 5000 years ago and that they didn't have the same graduations in learning and technology.

Riding a horse seems pretty basic, especially given that people back then are perceived as being closer to nature.

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Episimian t1_jb657fn wrote

Reply to comment by LawHelmet in Study reveals that although private automobiles continue to be the dominant travel mode in American cities, the share of car trips has slightly and steadily decreased since its peak in 2001. In contrast, the share of transit, non-motorized, and taxicab trips has steadily increased by giuliomagnifico

Many European cities are far less sprawling than in the US and encourage a mixed mass transit, cycling and walking commute - catch the train/tram/underground/bus for the longer part of your journey and then use a shared short rental bike to get to where you need to be. It's not perfect but it makes getting to work pretty easy where it works. Except in a Northern European winter - cycling in the pissing rain in the dark is never easy or fun.

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juntoalaluna t1_jb62flb wrote

Reply to comment by Agasthenes in Study reveals that although private automobiles continue to be the dominant travel mode in American cities, the share of car trips has slightly and steadily decreased since its peak in 2001. In contrast, the share of transit, non-motorized, and taxicab trips has steadily increased by giuliomagnifico

In some situations, a big chunk of traffic is people looking for parking. You don’t need to reduce the number of vehicles very much to significantly reduce the amount of traffic.

I think the best example of this is SFPark, where parking prices were (are?) managed to maintain 60-80% parking occupancy. People being able to park easily reduces congestion.

It’s obviously not a perfect example, as you could argue that not knowing the cost of parking is going to also reduce the number of drivers, but the study I read suggested the real benefit was from increasing parking efficiency. Taxis also increase parking efficiency by not really needing parking.

So taxis do kind of reduce the number of vehicles on the road (but obviously not as much as a bus!)

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Rain_Dont_Pour OP t1_jb625w7 wrote

Reply to comment by HeTakesYou in Interesting relationship between Chemoresistant Ovarian Cancer and Follistatin. Follistatin production increased chemoresistance by communicating with neighboring cells to promote quiescence. Could be a potential target for therapy in the most deadly gynecological cancer. by Rain_Dont_Pour

I'm not sure, I think everyone should receive treatment independently of their follistatin levels. I believe what they're trying to show is that having the high levels of the protein promotes chemoresistance.

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Rain_Dont_Pour OP t1_jb61xm4 wrote

Reply to comment by Economy_Appearance_9 in Interesting relationship between Chemoresistant Ovarian Cancer and Follistatin. Follistatin production increased chemoresistance by communicating with neighboring cells to promote quiescence. Could be a potential target for therapy in the most deadly gynecological cancer. by Rain_Dont_Pour

I think this is a hard question to respond since they didn't look into that mechanism, I believe the pathways of resistance are different, but maybe there could be a connection between both.

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Rain_Dont_Pour OP t1_jb61qjr wrote

Reply to comment by damnan99 in Interesting relationship between Chemoresistant Ovarian Cancer and Follistatin. Follistatin production increased chemoresistance by communicating with neighboring cells to promote quiescence. Could be a potential target for therapy in the most deadly gynecological cancer. by Rain_Dont_Pour

I believe what they're trying to say is that you would have to create an antibody that would block the action of follistatin so it doesn't bind to the receptor. I think the concept of lowering the levels of follistatin is not feasible, but it could be a possibility that the authors haven't looked into.

From my understanding, they were able to create cells that didn't produce follistatin and that's how they proved that absence of it made ovarian cancer cells more sensitive to chemo.

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