Recent comments in /f/science
[deleted] t1_jbxu0ws wrote
Reply to comment by Perpetual_Ronin in MDMA appears to confer resilience in a rodent model of chronic social defeat stress by chrisdh79
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[deleted] t1_jbxtq3s wrote
Reply to MDMA appears to confer resilience in a rodent model of chronic social defeat stress by chrisdh79
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B-Bog t1_jbxsq69 wrote
Reply to Breathwork may improve mood and change physiological states more effectively than mindfulness meditation by chrisdh79
They only did 5 minutes daily for both. I'd argue that
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breath work has a much smaller minimum effective dosage than meditation. That is to say, 5 minutes of breath work can fulfill the purpose of said breath work much better than 5 mins of meditation can fulfill the purpose of that activity. It takes our brain approximately 11 mins to truly focus on any given activity, so doing a focus meditation for less than 11 mins per day probably isn't going to achieve very much. And
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Meditation has a much steeper learning curve than breath work and can actually entail a lot of frustration and discomfort in the beginning. It's really not the relaxation or "stress management" exercise it is often marketed as here in the West, but a long-term project with the goal of increasing awareness. But as awareness grows, we are not going to like everything we become aware of. E.g. the first thing many people become aware of when meditating is how busy their mind actually is on a moment-to-moment basis, and how uncomfortable it is for them to sit down and not distract themselves with external stimuli. If you go into a meditation with the express purpose of changing your internal state, as you would with a breath exercise, you've really already lost the plot, because meditation is about acceptance and witnessing of the present moment as it is.
GlassEyeMV t1_jbxsfg4 wrote
Reply to comment by Falagard in MDMA appears to confer resilience in a rodent model of chronic social defeat stress by chrisdh79
My best friend and I now have a connection for mushrooms. We did them once together in college and now, we try to do them once every few years together just to hang out and reset our brains and have fun together. We usually just hang out, play with the dog, play a board game, go for walks around his neighborhood etc. Its great. With having a regular contact now, I think we’ll be doing it annually.
[deleted] t1_jbxqh37 wrote
Reply to comment by tylerderped in MDMA appears to confer resilience in a rodent model of chronic social defeat stress by chrisdh79
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[deleted] t1_jbxp86q wrote
Reply to MDMA appears to confer resilience in a rodent model of chronic social defeat stress by chrisdh79
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[deleted] t1_jbxox05 wrote
Reply to comment by Grouchy-Cod-5908 in Perceived time expands and contracts within each heartbeat by old_guitarist
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LiteralSymbolism t1_jbxo7qq wrote
Reply to comment by -downtone_ in Perceived time expands and contracts within each heartbeat by old_guitarist
Great ELI5, but I think you may have gotten those backwards? I’ve been trying to figure it out, but check this part of the paper:
“…with stimuli presented at diastole judged, on average, 9 ms longer (M = 305, SD = 25) than those at systole (M = 314, SD = 26).”
I think this saying in diastole (when the heart is beating), the time the participant felt an image was up was 9ms longer than when the heart wasn’t beating, and I would interpret that as time “expanding” since you feel like you’re spending a longer amount of time looking at a stimulus than you really are. Maybe this is just confusion about time “expanding” vs “contracting”.
Anyway, cool theory!
LiteralSymbolism t1_jbxn67m wrote
Reply to comment by spikedragonborn in Perceived time expands and contracts within each heartbeat by old_guitarist
You know how sometimes a few minutes or seconds feel really slow, or they go by super fast? This paper focused on the small side, on those few seconds that sometimes feel slow or fast, and they thought “hey maybe it’s related to the heart beating.”
So they went a proved a relationship between when your heart beats and the perceived passage of time, specifically during the 200-400 millisecond windows of “your heart is pumping blood” and “your heart is chilling, waiting to pump blood”. In the first state, time seemed to expand (ie felt longer), in the second state, time seemed to contract (or felt faster) according to study participants.
They also found that this effect nearly completely went away as one becomes more aroused, likely due to other more important factors like your brain interpreting something more interesting, which could easily muddy the results.
[deleted] t1_jbxhfke wrote
Reply to comment by el-em-en-o in MDMA appears to confer resilience in a rodent model of chronic social defeat stress by chrisdh79
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el-em-en-o t1_jbxf5tr wrote
Reply to comment by [deleted] in MDMA appears to confer resilience in a rodent model of chronic social defeat stress by chrisdh79
Why’d you quit?
[deleted] t1_jbxdscp wrote
Reply to comment by supbrah_ in MDMA appears to confer resilience in a rodent model of chronic social defeat stress by chrisdh79
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IsuzuTrooper t1_jbxcxqt wrote
Reply to comment by PoopIsAlwaysSunny in MDMA appears to confer resilience in a rodent model of chronic social defeat stress by chrisdh79
there wouldnt be war if everybody dosed.....almost
[deleted] t1_jbxcv6g wrote
Reply to comment by Bitter_Jackfruit8752 in MDMA appears to confer resilience in a rodent model of chronic social defeat stress by chrisdh79
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onomojo t1_jbxbhwn wrote
Reply to comment by ModsAreN0tGoodPeople in MDMA appears to confer resilience in a rodent model of chronic social defeat stress by chrisdh79
We used to call them rolls back in the day. Once you get a "dirty" roll you end up seeking that out. Dirty is just mixed with meth.
[deleted] t1_jbx94iz wrote
Reply to comment by Falagard in MDMA appears to confer resilience in a rodent model of chronic social defeat stress by chrisdh79
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-downtone_ t1_jbx6xa3 wrote
Reply to comment by nametag-username in Perceived time expands and contracts within each heartbeat by old_guitarist
At low arousal, as the heart contracts/beats, time seems to go by faster. As the heart relaxes, time seems to go by slower.
As arousal increases, the pattern I mentioned about the heart beat/relax cycle disappears. Under high arousal, it shifts towards feeling like time goes by faster regardless of the beat/relax cycle.
That's how I read this at least.
tyler1128 t1_jbx6pvv wrote
Reply to comment by NoNumbersAtTheEnding in MDMA appears to confer resilience in a rodent model of chronic social defeat stress by chrisdh79
I brought dissociatives up as I thought that was where you were talking to bringing up NMDA receptors.
You are right that all of these things affect more than just the the primary target, that being the reuptake, release, agonism/antagonism of the primary receptor target. Any drug affecting a monoamine neurotransmitter is going to have downstream effects on others, and many receptors have specific action on regulating feedback loops on the other neuorotransmitters.
I was really only speaking to the direct effect for brevity if nothing else. I'm also aware that the down-regulation of the serotonergic system over time is considered a likely part of the antidepressant mechanism of SSRIs. In general, I agree with pretty much everything you said.
> "Also as of like, last month, “we don’t know how psychedelics induce this neuroplastic change” is an outdated statement"
I hadn't seen that. Mind linking the paper? Sounds like an interesting read.
[deleted] t1_jbx65d5 wrote
Reply to comment by andy_bovice in MDMA appears to confer resilience in a rodent model of chronic social defeat stress by chrisdh79
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DrewzerB t1_jbx3po8 wrote
This is quite an interesting dynamic to the anecdotal evidence that time seems to move faster as we age. I wonder if there are similar mechanisms in the brain.
facthanshotfirst t1_jbwx31f wrote
Reply to comment by Falagard in MDMA appears to confer resilience in a rodent model of chronic social defeat stress by chrisdh79
It’s definitely something else. Last weekend my spouse and I took shrooms+mdma at a music festival and had the time of our lives. We watched ODESZA for the first time and it was such a magical experience for us. There’s such a fantastic connection with people and music when on it. I highly recommend it, if you can get it from people you trust and test it.
[deleted] t1_jbwskk6 wrote
Reply to comment by interleeuwd in MDMA appears to confer resilience in a rodent model of chronic social defeat stress by chrisdh79
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interleeuwd t1_jbws27v wrote
Reply to comment by Doesanybodylikestuff in MDMA appears to confer resilience in a rodent model of chronic social defeat stress by chrisdh79
Mushrooms + music is the best. No idea what sort of music you are into, but for me it’s pretty hard to beat Shpongle. His music is drugs by itself, but he has a way of just setting a trip off completely. It can definitely be too intense though, depending on where you are at in your trip
[deleted] t1_jbxudru wrote
Reply to comment by ZalmoxisRemembers in MDMA appears to confer resilience in a rodent model of chronic social defeat stress by chrisdh79
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