Recent comments in /f/science

kinda_alone t1_jbyy04h wrote

Someone recommended it to me. I had a bout of nerve pain following an accident myself. I was seeing some specialist who kept prescribing various nerve pain medicines. Nothing was working. Eventually she recommended I try a capsaicin cream, which did the trick for me. Not sure if it was a placebo or if there’s something actually to it, but god damn it was a life send

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VoldemortsBallsack t1_jbyu1ap wrote

I can personally attest to how well this works for a foot injury. I smashed a dolly for a boat hull onto the back of my Achilles tendon, I couldn't even put pressure on the foot or walk after hurting it. I put a capsaicin patch on it overnight and I woke up and had absolutely zero pain, like I was never hurt. Never tested it for back pain or other injuries but it definitely helps and worth a shot.

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Ill_Marsupial8785 t1_jbyt7q4 wrote

Let's strongman your "plants feel pain" claim. Then we better go vegan since animal livestock are fed plants, and we could reduce overall plant losses by eating plants directly rather than filtering them through an animal.

That being said, a plant is not sentient. Stabbing a dog and cutting a carrot are not equivalent and if you think they are you need some help.

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WhisperingShores t1_jbylrzz wrote

Interesting study, but it doesn't recognize individuals who are highly stimulated and yet perceive a slowed passage of time. We typically associate this perceived slow passage of time with a negative or noxious stimuli such as a danger, threat, or trauma. However, this perceived slowed time can also be experience in moments of positive stimuli.

It seems like an eternity when caught in the gaze of that beautiful or handsome person.

There is an earlier study one this phenomena that included consideration of the Sympathetic Nervous System. This is the system responsible for the "Flight or Flight" response and emotional responses to those stimuli.

However, this SNS response critically needs to be redefined as "Fight, Flight, or Freeze" response.

People can freeze in a moment of high stimulation and feel a slower passage of time, which is well documented. So my question is, when during such a Freeze Event, is the heart rate high or is there a sudden drop despite the high stimulation (shock)?

As far as I am concerned this is half a study and as such is misleading. The implication is that more is involved than just heart rate such as emotional state and awareness as to what is specifically occurring during the event.

The heart may be slowed in this Freeze while time is perceived to pass slower. This may be the body's and mind's way of protecting itself in the face of a sensory overload or too much stimulation. However, when we are overly stimulated we can forget details of an event, so this perceived slower passage of time allows for in increased remembrance of what occurred.

If the heart rate remains high during these Freezes, and the individual still experiences a high heart rate along with a slowed perceived time, this unless shock sets in, then the study is immediately debunked.

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Wagamaga OP t1_jbykkl5 wrote

People living with diabetes can be at a higher risk of nerve damage in parts of their body, known as neuropathy. If nerves are damaged in the feet, ulcers can develop, which can lead to amputations if left unchecked.

While symptoms of neuropathy can be treated, at the moment there aren’t any treatments that can reverse or halt the nerve damage.

For some people, neuropathy can also cause debilitating pain, which can be very difficult to treat with over-the-counter painkillers. People tend to be offered antidepressants to manage their pain, but this isn’t always successful and can come with a risk of side effects.

A hot topic in pain relief Capsaicin is a molecule found in chillis, which gives them their fiery kick. It can also help to block pain signals from nerves when it’s applied to skin, making them less sensitive to pain. So capsaicin creams and skin patches – which stick to areas where nerves have been damaged – can be really helpful to reduce pain.

There’s also evidence that capsaicin can boost healing in some skin conditions like psoriasis. But we don’t yet know if capsaicin can help to treat the underlying cause of nerve pain, and how to reverse damage.

With our funding, a team of researchers at Imperial College London and Sheffield Teaching Hospitals recruited 75 people with diabetes and neuropathy. They investigated the effects of treating their feet with a patch containing 8% capsaicin (a licensed treatment for neuropathy called Qutenza), with one application for 30 minutes.

They wanted to figure out how the patch works to relieve pain, by looking at whether it could improve nerve damage over the course of three months.

50 of the participants had neuropathic pain, of which 32 were treated with the capsaicin patch and 18 received the current standard care for their pain. The other 25 participants didn’t have pain, but their neuropathy was still treated with the capsaicin patch.

During the study, participants were asked to keep a pain diary where they rated and described their pain, filled in questionnaires about their symptoms, and had their nerve sensitivity tested. They also gave samples of skin from their feet at the start and end of the study, and the researchers counted and analysed the nerves.

What the study found After three months, the team found that those who’d been treated with the capsaicin patch reported that their pain had reduced significantly, compared to those treated with standard care.

Excitingly, everyone who’d been treated with the capsaicin patch appeared to have more new nerves in their skin samples at the end of the study. This suggests that part of capsaicin’s role in lowering pain is by helping to heal the nerves and triggering them to grow back.

https://pubmed.ncbi.nlm.nih.gov/36388188/

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