Recent comments in /f/science

onyerbikedude t1_jc1y9fh wrote

Reply to comment by BafangFan in New information about the role of a molecule found in chillis in reducing foot pain by healing damaged nerves. After three months, the team found that those who’d been treated with the capsaicin patch reported that their pain had reduced significantly, compared to those treated with standard care by Wagamaga

Yeah. I'm middle aged now and find myself craving meat (whereas I spent year as a varsity student in a vegetarian flat with no pain incurred whatsoever). I eat meat, fruit, nuts, vegetables and sometimes carbohydrates and occasionally chocolate. I always cook my own food. I feel healthier than I have in decades.

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onyerbikedude t1_jc1xy62 wrote

Reply to comment by Man_Bear_Beaver in New information about the role of a molecule found in chillis in reducing foot pain by healing damaged nerves. After three months, the team found that those who’d been treated with the capsaicin patch reported that their pain had reduced significantly, compared to those treated with standard care by Wagamaga

You can use milk if you do that. It neutralises the chili immediately

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Technical_Sir_9588 t1_jc1xrfi wrote

Reply to comment by snappedscissors in New information about the role of a molecule found in chillis in reducing foot pain by healing damaged nerves. After three months, the team found that those who’d been treated with the capsaicin patch reported that their pain had reduced significantly, compared to those treated with standard care by Wagamaga

What I understand from some other research is that when these peripheral nerves become sensitized they spontaneous sends afferent signaling to the spinal cord - > brain without any external stimuli. This sustained signaling drives central sensitization. The idea is that central nervous system plasticity allows the reversal from central sensitization to the norm if these external stimuli reinforcing the [pain/damage/harm] are removed, especially since no actual sustained damage to the tissues is present.

I also educate my patients on the benefits of prolonged fasting, with the potential "repair" of peripheral nerves, spinal cord, etc. via autophagy. There is definitely research out there using mouse subjects and I wish more research funds would go towards this end but fasting isn't sexy more is its profitable.

The combo of fasting and capsaicin seem to provide the best outcomes.

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snappedscissors t1_jc1w1q2 wrote

Reply to comment by Technical_Sir_9588 in New information about the role of a molecule found in chillis in reducing foot pain by healing damaged nerves. After three months, the team found that those who’d been treated with the capsaicin patch reported that their pain had reduced significantly, compared to those treated with standard care by Wagamaga

You should check out the recent research on the receptors TRPV1 and TRPA1, among others. They are best known as external environment sensors, as receptors for heat and capsaicin. In the last decade or so work has shown them to be present in the central nervous system as well. Which begs the question: what is the effect of activating these receptors in neurons and nerve cells? Because the brain isn't getting much direct exposure to hot sauce right?

I read one paper recently looking at capsaicin as an agonist against TRPV1 in mouse neurons in a model for Alzheimer's disease. They showed rescue of a number of metabolic defects seen in neuronal cells during this disease, including increased mitochondrial metabolism. This might indicate a refresh of mitochondria, or a general increase in energy production.

A bunch of research groups are working on receptors like these now, trying to see where they are being activated and by what. They may have applications like this paper, or more!

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Croquetas_ t1_jc1osfo wrote

Reply to comment by its_ean in Researchers say derelict objects left in orbit and other disintegrating space junk may cause a catastrophic collision above our atmosphere. They warn that they would destroy communication systems, setting modern society back decades. by Wagamaga

Because it is. Every day that passes is more and more worrying. Aswell is because many scientists is calling now to action again, so yes, it's important

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