The following submission statement was provided by /u/Ezekiel_W:

>By packaging lipid nanoparticles with elements that decrease the fibrous nature of solid tumors, researchers can deliver CRISPR therapies in a more efficient manner.
>
>In a paper recently published in Nature Nanotechnology, Siegwart and his team developed a dual approach using LNPs equipped with tools that allow them to access and modify the tumor.4 The researchers packaged the LNPs with a CRISPR-Cas9 system that genetically modified and disrupted PD-L1 gene expression. PD-L1 overexpression inhibits T cell infiltration within the tumor microenvironment, so deactivating the gene allows immune cells to access the tumor. To grant the CRISPR system and immune cells tumor access, the LNP also included siRNA that targeted and reduced the expression of focal adhesion kinase (FAK), which diminished the density of the extracellular matrix surrounding the tumor.

This is really good news. One of the biggest challenges with mRNA and CRISPR therapies for cancer treatments is penetrating solid tumors.

Please reply to OP's comment here: https://old.reddit.com/r/Futurology/comments/y1h0xb/researchers_develop_a_crisprbased_therapy_that/irxa6nl/

The following submission statement was provided by /u/PeteWenzel:

EVs have gone from less than 1% of light commercial vehicle sales to 10% in just the last two years. Sales reached a record high of almost 18,000 in August and look likely to keep rising in the final few months of the year.

Most major oil outlooks now acknowledge that passenger vehicle oil demand has either already peaked or will soon. But almost all of them assume steady growth in demand from the commercial vehicle segment as countries get richer and more freight continues to be moved by road.

In BNEF’s 2022 Road Fuel Outlook, commercial vehicle growth keeps oil demand growing, but not for long. This year’s outlook has overall road transport oil demand peaking in 2027, but if sales of electric trucks continue to rise sharply in China, that could be pulled forward.

https://archive.ph/pA30p

Please reply to OP's comment here: https://old.reddit.com/r/Futurology/comments/y1eklp/chinas_electric_trucks_may_well_pull_forward_peak/irwv2y6/

The following submission statement was provided by /u/WallStreetDoesntBet:

Unlike airplanes and helicopters, eVTOL (electric vertical takeoff and landing) vehicles offer quick point-to-point personal travel, at least in principle.

The pilot-less vehicles could one day ferry passengers across town high above congested roadways. But the sector still faces major challenges, including battery life, air traffic control and safety, and infrastructure issues.

Please reply to OP's comment here: https://old.reddit.com/r/Futurology/comments/y1bwgu/firm_tests_electric_flying_taxi_xpeng_x2_in_dubai/irweko1/

The following submission statement was provided by /u/Always__curious__:

Solar, wind and hydro represented 46 per cent of the nation’s power mix in the eight months to August this year. Could we see other countries scaling up in the future and following their lead, especially in light of the nergy/cost of living crisis?

Please reply to OP's comment here: https://old.reddit.com/r/Futurology/comments/y1bn9b/major_milestone_for_greek_energy_as_renewables/irwd1oq/

The following submission statement was provided by /u/noelcowardspeaksout:

Lots of fusion plants are energy positive for fractions of a second. This plant, due to improvements in magnetic field density, is actually designed to harvest that energy, turn it into electricity and to supply the national grid with power.

Please reply to OP's comment here: https://old.reddit.com/r/Futurology/comments/y1akde/uk_to_build_first_grid_connected_fusion_power/irw764x/

The following submission statement was provided by /u/filosoful:

Geothermal systems carry warmth from Earth’s interior up to the surface for heating or electricity. But geothermal power plants are expensive to build, and will get even less economically viable as wind and solar power get cheaper and more plentiful. However, even as wind and solar grow, so does the need to store electricity from those temperamental sources.

A new proposal could solve those issues and bolster all three renewable technologies. The idea is simple—use advanced geothermal reservoirs to store excess wind and solar power in the form of hot water or steam, and bring up that heat when wind and solar aren’t available, to turn turbines for electricity.

>It would allow next-generation geothermal plants to break from the traditional baseload operating paradigm and earn much greater value as suppliers of wind and solar,

says Wilson Ricks, a graduate student in mechanical and aerospace engineering at Princeton University.

Please reply to OP's comment here: https://old.reddit.com/r/Futurology/comments/y16ixm/geothermal_may_beat_batteries_for_energy_storage/irvklbm/

The following submission statement was provided by /u/CannoliIntoPussy:

Need nuclear, now, stat. Long-term planning means starting nuclear projects today. It’s not that easy to hit 300 characters on this topic; nuclear has energy density unmatched by any other known energy source and, for that reason, it needs to be the future. NIMBYs will fight almost any energy source, and any means of energy transmission, tragically.

Please reply to OP's comment here: https://old.reddit.com/r/Futurology/comments/y0y6ry/solar_rollout_rouses_resistance_in_europes/irui0g7/

The following submission statement was provided by /u/Apart_Shock:

>Researchers at Boston’s Northeastern University have built a device using new artificial intelligence techniques that can recognise “millions of colours”, opening the door to a new world of industrial machine vision applications.
>
>A-Eye is capable of analysing and processing colour far more accurately than existing machines, according to a paper detailing the research published in Materials Today. Researchers say the new device represents “a massive step” in the field of machine vision and has broad applications for a range of technologies.

Please reply to OP's comment here: https://old.reddit.com/r/Futurology/comments/y0we0s/quantum_windows_mean_machines_can_see_millions_of/iru6zj7/

The following submission statement was provided by /u/climeworks:

We're at a point where reduction is not enough anymore. We need to remove emissions as well.

To be specific: The United Nations body for assessing the science related to climate change (IPCC) says the use of carbon removal technologies is already “unavoidable” if we want to meet our climate goals, and that by 2050 we’ll need to remove and store 5-16 billion tons per year.

Companies that produce technologies to remove or reduce carbon emissions are “poised for strong continued growth,” reaching an expected value of $1.4 trillion by 2027, according to new market research.

PitchBook predicts that the emerging sector will enjoy an 8.8 percent growth rate over the next five years, “thanks to increasing global focus on aggressive emissions targets and consumer interest in emissions reduction.” That rate could also increase if there were “dramatic regulatory change or technological innovation” during that time, the report for investors said.

Please reply to OP's comment here: https://old.reddit.com/r/Futurology/comments/y0er0z/the_emerging_climate_tech_sector_will_enjoy_an_88/irrb8k7/

The following submission statement was provided by /u/Give-Directly:

AI targeting aid after a disaster is faster and often more accurate than traditional assessments. However, it is in and of itself incomplete - people in need will be missed. Can this technology work in concert with traditional on the ground approaches to respond to climate disasters?

Please reply to OP's comment here: https://old.reddit.com/r/Futurology/comments/y0ejls/hurricane_ian_destroyed_their_homes_algorithms/irraaw1/

The following submission statement was provided by /u/Gari_305:

From the Article

>Someone who speaks low and slowly might have Parkinson's disease. Slurring is a sign of a stroke. Scientists could even diagnose depression or cancer. The team will start by collecting the voices of people with conditions in five areas: neurological disorders, voice disorders, mood disorders, respiratory disorders and pediatric disorders like autism and speech delays.
>
>The project is part of the NIH's Bridge to AI program, which launched over a year ago with more than $100 million in funding from the federal government, with the goal of creating large-scale health care databases for precision medicine.

Please reply to OP's comment here: https://old.reddit.com/r/Futurology/comments/y0brkr/ai_app_could_diagnose_illnesses_based_on_speech/irqwlm2/

The following submission statement was provided by /u/Soupjoe5:

Article:

1

Just a couple of years ago, it seemed that space mining was inevitable. Analysts, tech visionaries and even renowned astrophysicist Neil deGrasse Tyson predicted that space mining was going to be big business.

Space mining companies like Planetary Resources and Deep Space Industries, backed by the likes of Google ’s Larry Page and Eric Schmidt, cropped up to take advantage of the predicted payoff.

Fast forward to 2022, and both Planetary Resources and Deep Space Industries have been acquired by companies that have nothing to do with space mining. Humanity has yet to commercially mine even a single asteroid. So what’s taking so long?

Space mining is a long-term undertaking and one that investors do not necessarily have the patience to support.

“If we had to develop a full-scale asteroid mining vehicle today, we would need a few hundred million dollars to do that using commercial processes. It would be difficult to convince the investment community that that’s the right thing to do,” says Joel Sercel, president and CEO of TransAstra Corporation.

“In today’s economics and in the economics of the near future, the next few years, it makes no sense to go after precious metals in asteroids. And the reason is the cost of getting to and from the asteroids is so high that it vastly outstrips the value of anything that you’d harness from the asteroids,” Sercel says.

This has not dissuaded Sercel from trying to mine the cosmos. TransAstra will initially focus on mining asteroids for water to make rocket propellant, but would like to eventually mine “everything on the periodic table.” But Sercel says such a mission is still a ways off.

“In terms of the timeline for mining asteroids, for us, the biggest issue is funding. So it depends on how fast we can scale the business into these other ventures and then get practical engineering experience operating systems that have all the components of an asteroid mining system. But we could be launching an asteroid mission in the 5 to 7-year time frame.”

Sercel hopes these other ventures keep it afloat until it develops its asteroid mining business. The idea is to use the tech that will eventually be incorporated into TransAstra’s astroid mining missions to satisfy already existing market needs, such as using space tugs to deliver satellites to their exact orbits and using satellites to aid in traffic management as space gets increasingly more crowded.

Please reply to OP's comment here: https://old.reddit.com/r/Futurology/comments/xztlx1/the_first_crop_of_space_mining_companies_didnt/iro4kos/

The following submission statement was provided by /u/asbruckman:

I found this podcast fascinating. While early search for extraterrestrial intelligent life looked for radio signals, newer work is looking for "technosignals" like signs of pollution. There are two new space telescopes being designed specifically with features to look for these technosignals. If either is launched, it will be two decades from now or longer. The challenging science problem right now is: what signals should we look for?

There was an interesting discussion of the fact that many exoplanets are covered in water. If an intelligent species evolved that was aquatic, what kinds of technologies might they develop and what would signals of their tech look like?

Please reply to OP's comment here: https://old.reddit.com/r/Futurology/comments/xznoru/podcast_the_search_for_extraterrestrial/irn3uby/

The following submission statement was provided by /u/Gari_305:

From the Article

>The Australian National University (ANU) will lend its unique expertise in plant biology to an ambitious mission led by Australian space start-up Lunaria One that aims to grow plants on the moon by as early as 2025. 
>
>Lunaria One's Australian Lunar Experiment Promoting Horticulture (ALEPH) will be the first in a series of experiments to investigate whether plants can not only tolerate but thrive on the lunar surface. The project is an early step toward growing plants for food, medicine and oxygen production, which are all crucial to establishing human life on the moon. 

Which leads to an interesting question, with the fact that plants can be grown on lunar soil and the fact that both the US and China is making a play for the lunar body due to the Helium 3 resource, are we looking at the beginnings of a new colonization era only this time it'll be in Space?

Please reply to OP's comment here: https://old.reddit.com/r/Futurology/comments/xz66mh/anu_to_support_aussie_startup_in_growing_plants/irkgzzm/

The following submission statement was provided by /u/Defiant_Swann:

In the future, humans will use AI to create AI, maybe a better one. What does this mean? Well, a thousand things, if not more.

Please reply to OP's comment here: https://old.reddit.com/r/Futurology/comments/xywsfd/well_build_ai_to_use_ai_to_create_ai/irj2izn/

The following submission statement was provided by /u/filosoful:

About 15 years ago, government incentives helped to launch a biofuel boom in the United States. Ethanol factories now consume about 130 million metric tons of corn every year. It’s about a third of the country’s total corn harvest, and growing that corn requires more than 100,000 square kilometers of land.

In addition, more than 4 million metric tons of soybean oil is turned into diesel fuel annually, and that number is growing fast.

Scientists have long warned that biofuel production on this scale involves costs: It claims land that otherwise could grow food or, alternatively, grass and trees that capture carbon from the air and provide a home for birds and other wildlife.

But government agencies, relying on the results of economic models, concluded that those costs would be modest, and that replacing gasoline with ethanol or biodiesel would help to meet greenhouse gas reduction goals.

Please reply to OP's comment here: https://old.reddit.com/r/Futurology/comments/xyvzzm/how_green_are_biofuels_scientists_are_at/irixmex/

The following submission statement was provided by /u/Lennycool:

BMI's, Remote Work, Algorithmic feeds, Gene editing will fundamentally change society and in this article I explore some of the effects

Please reply to OP's comment here: https://old.reddit.com/r/Futurology/comments/xyv0oq/how_technology_changes_society/iritpwr/

The following submission statement was provided by /u/Educational_Sector98:

The electric car largely reduces the emission of particulate matter and microplastics caused by the abrasion of tyres and brakes, according to the DLR’s official website. I thought I've seen other prototypes years before that made the same innovation, or am i wrong?

Please reply to OP's comment here: https://old.reddit.com/r/Futurology/comments/xyp7fq/germans_zedu_car_is_most_environmentally_friendly/iri3drv/

The following submission statement was provided by /u/Soupjoe5:

Article:

1

Falling launch costs for satellites mean space advertising may now make commercial sense, according to a feasibility study, but the idea remains controversial

Constellations of satellites that reflect sunlight to Earth could be used for space advertising at a commercially viable cost of $65 million per mission, according to a feasibility study. But the idea is controversial among researchers, who warn of a pile-up of dangerous space debris and light pollution for ground and space-based telescopes.

Previous proposals for space advertising didn’t make commercial sense – the cost of launching enough satellites, which tend to remain in the correct orbit for only a short amount of time, has been prohibitive for any serious attempts.

But as launch costs have decreased with the advent of private space companies, Shamil Biktimirov at the Skolkovo Institute of Science and Technology in Moscow, Russia, and his colleagues think it could now be viable if the mechanics of how the satellites are used as advertising are reassessed.

To do this, they borrowed techniques that describe the dynamics of mega-constellations, such as that of Starlink’s communications satellite fleet, and used this to calculate how much revenue companies could get for keeping their satellites in the sky for certain lengths of time.

They propose that a fleet of about 50 satellites equipped with curved reflectors could orbit around the line where day turns to night and reflect the sun’s light to a patch of ground below. They would be arranged to form an image made of bright pixels showing a logo or a basic image. Viewers on the ground would see the constellation move across the sky in around 10 minutes around dawn or dusk, growing from half-moon size to two to three times bigger than the moon at its peak.

To maximise revenue, the satellites would change formation around 25 times to target different locations in a three month period of operation before the satellites run out of fuel and slowly descend towards Earth and – Biktimirov hopes – burn up.

But this long descent could be a problem. “The spaceflight risk from debris related to these objects is considerable,” says John Barentine of Dark Sky Consulting, a company based in Tucson, Arizona. “Left derelict in orbits with long lifetimes, every single object becomes a potential ‘bullet’ that threatens every other object in similar orbits. Any one might set off a catastrophic cascade of debris generation.”

Please reply to OP's comment here: https://old.reddit.com/r/Futurology/comments/xy8cm2/space_adverts_are_now_economically_viable_but/irfv0nr/

The following submission statement was provided by /u/Sariel007:

>In July, an HIV-positive man became the first volunteer in a clinical trial aimed at using Crispr gene editing to snip the AIDS-causing virus out of his cells. For an hour, he was hooked up to an IV bag that pumped the experimental treatment directly into his bloodstream. The one-time infusion is designed to carry the gene-editing tools to the man’s infected cells to clear the virus.

>Later this month, the volunteer will stop taking the antiretroviral drugs he’s been on to keep the virus at undetectable levels. Then, investigators will wait 12 weeks to see if the virus rebounds. If not, they’ll consider the experiment a success. “What we’re trying to do is return the cell to a near-normal state,” says Daniel Dornbusch, CEO of Excision BioTherapeutics, the San Francisco-based biotech company that’s running the trial.

Please reply to OP's comment here: https://old.reddit.com/r/Futurology/comments/xxyhgb/a_bold_effort_to_cure_hivusing_crispr/iree9ir/

The following submission statement was provided by /u/Gari_305:

From the Article

>Innovations in artificial intelligence are making it faster and cheaper for political campaigns to identify, turn out and extract money from voters.
>
>The big picture: Consultants for both major parties are hoovering up voter data to hone advanced fundraising and persuasion tactics. These data tools are especially useful in down-ballot local races.

As politicians revert to AI for their political efforts, the question arises in the form of does the influence of these political campaigners over their operations get reduced with the advent of these AI systems?

What effect would AI have on our political environment in the years to come?

Please reply to OP's comment here: https://old.reddit.com/r/Futurology/comments/xxwuue/ai_becomes_a_political_superweapon/ire71dz/

The following submission statement was provided by /u/izumi3682:

Submission statement from OP. Note: This submission statement "locks in" after about 30 minutes, and can no longer be edited. Please refer to my statement they link, which I can continue to edit. I often edit my submission statement, sometimes for the next few days if needs must. There is often required additional grammatical editing and additional added detail.

From the article.

>“Just as our Constitution’s Bill of Rights protects our most basic civil rights and liberties from the government, in the 21st century, we need a ‘bill of rights’ to protect us against the use of faulty and discriminatory artificial intelligence that infringes upon our core rights and freedoms,” ReNika Moore, director of the American Civil Liberties Union’s Racial Justice Program, says.

>“Unchecked, artificial intelligence exacerbates existing disparities and creates new roadblocks for already-marginalized groups, including communities of color and people with disabilities. When AI is developed or used in ways that don’t adequately take into account existing inequities or is used to make decisions for which it is inappropriate, we see real-life harms such as biased, harmful predictions leading to the wrongful arrest of Black people, jobs unfairly denied to women, and disparate targeting of children of color for removal from their families. The Blueprint for an AI Bill of Rights is an important step in addressing the harms of AI.”

I don't know whether this development is too little, too late or not. I see AI is explosively evolving before our eyes. I know that new iterations of already existing extraordinarily powerful and impactful AIs are going to be released in just this next year alone, if not actually this year. I know that, for example GPT-4 which compared to the currently powerful and controversial GPT-3, is going to demonstrate new powers of AI that we might have thought were impossible. All of this is developing with incredible rapidity.

And like I have always maintained, these AIs do not have to be conscious or self aware at all. But I bet this next generation of AI will make a lot of people think it is conscious and self-aware.

So I watched this video where the researchers are testing various GPT-3 NLP AIs with varying conditions intrinsic to the AIs being tested. One is where an AI has hostile regards to humans. I know it is just a test and can't go anywhere (I hope). The idea being that we want to find where a given AI can have dangerous to humans, sentiments and settle down those sentiments quickly. If such a thing is possible if an AI actually gets "mad" at us for reasons.

Here is a video that shows a testing AI get angry and threatening towards humans. I don't think this is staged, but I could be wrong. It's hard to tell for sure with AI these days. Even a highly trained AI expert was apparently completely fooled by an AI that had no idea what it was communicating. He was not alone. Some other highly trained AI experts also were feeling substantial unease as to how fast these NLP programs were progressing. If these AIs can fool the experts, what chance do us hoi polloi laymen have? Anyway, here is a video concerning that. Just ignore the Elon Musk parts. I want you to see these conversations with these GPT-3 AIs.

https://www.youtube.com/watch?v=Fbc1Xeif0pY&t=112s (6 Oct 22)

Please reply to OP's comment here: https://old.reddit.com/r/Futurology/comments/xxelcu/white_house_releases_blueprint_for_artificial/irbpbnh/

The following submission statement was provided by /u/PhilipGreenbriar:

As more intense storms threaten the livability of places like coastal Florida, this community in Fort Meyers, FL is employing smart, sustainable solutions to weather what comes. I know several people who were personally affected by the recent hurricane and I hope that developers, utility companies, and the state and local governments can adapt to protect residents.

Please reply to OP's comment here: https://old.reddit.com/r/Futurology/comments/xxc10h/a_florida_community_built_to_weather_hurricanes/irb7g07/

The following submission statement was provided by /u/Ezekiel_W:

>While many cultivated meat and seafood companies employ “adherent” techniques that attach growing cells to microcarriers, BlueNalu says it has developed non-GMO cell lines in single cell suspension, meaning large numbers of cells can freely grow in bioreactors without the need for costly microcarriers.
>
>In addition, BlueNalu reveals its patent-pending lipid-loading technology allows cultivated muscle cells to actively store fat, eliminating the need to grow muscle and fat cells in separate bioreactors. This technique is projected to significantly reduce capital expenditures, the company says, and will create products with higher fat profiles and better taste, texture and mouthfeel attributes.

Please reply to OP's comment here: https://old.reddit.com/r/Futurology/comments/xxa8m1/bluenalu_says_breakthrough_tech_cracks_the_code/irawdm6/

The following submission statement was provided by /u/Gari_305:

From the Article

>The footage begins with a shot of the drone as it approaches the rooftop of a building in a nondescript urban area with the compact armed robot dog being carried under the drone’s frame. The drone, acting as a robotic dropship of sorts, then lands atop the roof, releases the robodog, and flies away. Shortly thereafter the robodog unfurls from its folded position and begins navigating its new surroundings with what looks to be a Chinese QBB-97 light machine gun (designated as Type 95 LGM in the United States) mounted on its back.

Is this the future of warfare, utilizing robots in such a manner?

Please reply to OP's comment here: https://old.reddit.com/r/Futurology/comments/xx8avz/china_pairs_armed_robot_dogs_with_drones_that_can/irak504/