UseYourThumb
UseYourThumb t1_j5uk896 wrote
Reply to i was reading an article that mentions GABA and how different isoforms mediate “fast” and “slow” hyperpolarization. what is meant by “fast” and “slow” in the context of hyperpolarization? by Unknown_Predator88
Could you link the paper? It is hard to know what you are referring to based on this question alone. I'm guessing you are talking about fast or slow afterhyperpolarizations, which are usually mediated by different types of calcium dependent potassium channels with faster or slower kinetics. I suppose you could also be talking about the activation of GABA-A versus GABA-B receptors. GABA-A receptors are ion channels that mediate fast chloride entry into the cell when GABA binds versus GABA-B receptors that are g-protein coupled receptors and act much more slowly.
UseYourThumb t1_j5wa8ui wrote
Reply to comment by Unknown_Predator88 in i was reading an article that mentions GABA and how different isoforms mediate “fast” and “slow” hyperpolarization. what is meant by “fast” and “slow” in the context of hyperpolarization? by Unknown_Predator88
I agree with the paper, I don't think I would technically call it an agonist. Read sections 6, 7, and 8 of this more recent review for a better explanation.